Prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer: a systematic review and meta-analysis
ObjectivesTo report the largest systematic review and meta-analysis to evaluate prognostic value of lymphocyte to monocyte ratio (LMR) in patients with esophageal cancer.MethodsWe conducted a systematic literature retrieval via PubMed, Embase, Web of Science, and Cochrane until December, 2023 for st...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1401076/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850161693536026624 |
|---|---|
| author | Yongqi Han Yongqi Han Yongqi Han Yongqi Han Song Zheng Song Zheng Song Zheng Song Zheng Yijing Chen Yijing Chen Yijing Chen Yijing Chen |
| author_facet | Yongqi Han Yongqi Han Yongqi Han Yongqi Han Song Zheng Song Zheng Song Zheng Song Zheng Yijing Chen Yijing Chen Yijing Chen Yijing Chen |
| author_sort | Yongqi Han |
| collection | DOAJ |
| description | ObjectivesTo report the largest systematic review and meta-analysis to evaluate prognostic value of lymphocyte to monocyte ratio (LMR) in patients with esophageal cancer.MethodsWe conducted a systematic literature retrieval via PubMed, Embase, Web of Science, and Cochrane until December, 2023 for studies which evaluated the prognostic value of LMR in patients with esophageal cancer. Outcomes measured were overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), and progression-free survival (PFS).Results11 studies including 3,377 patients with esophageal cancer were included for meta-analysis. Meta-analysis demonstrated that OS (HR: 1.65; 95% CI: 1.19, 2.31; P = 0.003) and DFS (HR: 1.48; 95% CI: 1.09, 2.01; P = 0.01) were significantly shorter in the low LMR group compared with the high LMR group. In addition, meta-analysis revealed a similar PFS (HR: 1.58; 95% CI: 1.00, 2.51; P = 0.05) and RFS (HR: 1.17; 95% CI: 0.93, 1.46; P = 0.18) in the two groups. Subgroup analysis found that the predictive value of LMR for OS remained significant in resectable and unresectable esophageal cancers, and in studies with follow-up ≥24 months and < 24 months. Subgroup analysis based on treatment methods found that the prognostic value of LMR was significant for both patients who received PD-1/PD-L1 inhibitors and those who did not receive PD-1/PD-L1 inhibitors. However, subgroup analysis based on LMR threshold found that the significance remained in studies with LMR threshold<3.5 (HR: 2.09; 95% CI: 1.13, 3.87; P = 0.02) but disappeared in studies with LMR threshold ≥ 3.5 (HR: 1.39; 95% CI: 0.93, 2.07; P = 0.11).ConclusionsLow LMR is associated with poor prognosis in patients with esophageal cancer. Due to the simple availability and low cost of routine blood tests in clinical practice, LMR can be widely used to assess prognosis and construct risk prediction models for patients with esophageal cancer.Systematic review registrationPROSPERO, identifier CRD42024509796. |
| format | Article |
| id | doaj-art-37b3ce75851c4ed28d6148eae4b421af |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-37b3ce75851c4ed28d6148eae4b421af2025-08-20T02:22:45ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.14010761401076Prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer: a systematic review and meta-analysisYongqi Han0Yongqi Han1Yongqi Han2Yongqi Han3Song Zheng4Song Zheng5Song Zheng6Song Zheng7Yijing Chen8Yijing Chen9Yijing Chen10Yijing Chen11Department of Oncology, The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Oncology, Hangzhou First People’s Hospital, Hangzhou, ChinaDepartment of Oncology, Hangzhou Cancer Hospital, Hangzhou, ChinaKey Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou First People’s Hospital, Hangzhou, ChinaDepartment of Oncology, The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Oncology, Hangzhou First People’s Hospital, Hangzhou, ChinaDepartment of Oncology, Hangzhou Cancer Hospital, Hangzhou, ChinaKey Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou First People’s Hospital, Hangzhou, ChinaDepartment of Oncology, Hangzhou First People’s Hospital, Hangzhou, ChinaDepartment of Oncology, Hangzhou Cancer Hospital, Hangzhou, ChinaKey Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou First People’s Hospital, Hangzhou, ChinaDepartment of Oncology, Zhejiang University School of Medicine, Hangzhou, ChinaObjectivesTo report the largest systematic review and meta-analysis to evaluate prognostic value of lymphocyte to monocyte ratio (LMR) in patients with esophageal cancer.MethodsWe conducted a systematic literature retrieval via PubMed, Embase, Web of Science, and Cochrane until December, 2023 for studies which evaluated the prognostic value of LMR in patients with esophageal cancer. Outcomes measured were overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), and progression-free survival (PFS).Results11 studies including 3,377 patients with esophageal cancer were included for meta-analysis. Meta-analysis demonstrated that OS (HR: 1.65; 95% CI: 1.19, 2.31; P = 0.003) and DFS (HR: 1.48; 95% CI: 1.09, 2.01; P = 0.01) were significantly shorter in the low LMR group compared with the high LMR group. In addition, meta-analysis revealed a similar PFS (HR: 1.58; 95% CI: 1.00, 2.51; P = 0.05) and RFS (HR: 1.17; 95% CI: 0.93, 1.46; P = 0.18) in the two groups. Subgroup analysis found that the predictive value of LMR for OS remained significant in resectable and unresectable esophageal cancers, and in studies with follow-up ≥24 months and < 24 months. Subgroup analysis based on treatment methods found that the prognostic value of LMR was significant for both patients who received PD-1/PD-L1 inhibitors and those who did not receive PD-1/PD-L1 inhibitors. However, subgroup analysis based on LMR threshold found that the significance remained in studies with LMR threshold<3.5 (HR: 2.09; 95% CI: 1.13, 3.87; P = 0.02) but disappeared in studies with LMR threshold ≥ 3.5 (HR: 1.39; 95% CI: 0.93, 2.07; P = 0.11).ConclusionsLow LMR is associated with poor prognosis in patients with esophageal cancer. Due to the simple availability and low cost of routine blood tests in clinical practice, LMR can be widely used to assess prognosis and construct risk prediction models for patients with esophageal cancer.Systematic review registrationPROSPERO, identifier CRD42024509796.https://www.frontiersin.org/articles/10.3389/fonc.2024.1401076/fulllymphocytemonocyteprognosis analysisesophageal cancermeta-analysis |
| spellingShingle | Yongqi Han Yongqi Han Yongqi Han Yongqi Han Song Zheng Song Zheng Song Zheng Song Zheng Yijing Chen Yijing Chen Yijing Chen Yijing Chen Prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer: a systematic review and meta-analysis Frontiers in Oncology lymphocyte monocyte prognosis analysis esophageal cancer meta-analysis |
| title | Prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer: a systematic review and meta-analysis |
| title_full | Prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer: a systematic review and meta-analysis |
| title_fullStr | Prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer: a systematic review and meta-analysis |
| title_short | Prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer: a systematic review and meta-analysis |
| title_sort | prognostic value of lymphocyte to monocyte ratio in patients with esophageal cancer a systematic review and meta analysis |
| topic | lymphocyte monocyte prognosis analysis esophageal cancer meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1401076/full |
| work_keys_str_mv | AT yongqihan prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT yongqihan prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT yongqihan prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT yongqihan prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT songzheng prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT songzheng prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT songzheng prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT songzheng prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT yijingchen prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT yijingchen prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT yijingchen prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis AT yijingchen prognosticvalueoflymphocytetomonocyteratioinpatientswithesophagealcancerasystematicreviewandmetaanalysis |