A question of TiME: how microenvironmental interactions shape response to immunotherapy in CLL and Richter Transformation

A question of TiME: how microenvironmental interactions shape response to immunotherapy in CLL and Richter Transformation

Immunotherapy has revolutionized the treatment landscape for many cancers, including some B- cell lymphomas. Immune checkpoint blockade, CAR-T cells and bispecific antibodies have shown promise for the treatment of Richter Transformation (RT) but have displayed reduced activity in chronic lymphocyti...

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Bibliographic Details
Main Authors: Alexander F. vom Stein, Phuong-Hien Nguyen, Elisa ten Hacken
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
microenvironment
chronic lymphocytic leukemia
Richter Transformation
immunotherapy
mouse models
preclinical studies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592574/full
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