Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders
BackgroundPsychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear. Sleep disturbances are common in psychosis, and emerging evidence suggests that sleep plays a critical role in WM physiolo...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1456435/full |
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| author | Umit Haluk Yesilkaya Umit Haluk Yesilkaya Xi Chen Xi Chen Lauren Watford Emma McCoy Meltem Sen Ilgin Genc Fei Du Fei Du Dost Ongur Dost Ongur Cagri Yuksel Cagri Yuksel |
| author_facet | Umit Haluk Yesilkaya Umit Haluk Yesilkaya Xi Chen Xi Chen Lauren Watford Emma McCoy Meltem Sen Ilgin Genc Fei Du Fei Du Dost Ongur Dost Ongur Cagri Yuksel Cagri Yuksel |
| author_sort | Umit Haluk Yesilkaya |
| collection | DOAJ |
| description | BackgroundPsychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear. Sleep disturbances are common in psychosis, and emerging evidence suggests that sleep plays a critical role in WM physiology. Therefore, it is plausible that sleep disturbances are associated with impaired WM integrity in these disorders. To test this hypothesis, we examined the association of self-reported sleep disturbances with WM transverse (T2) relaxation times in a cross-diagnostic sample of patients with psychosis.MethodsA total of 28 patients with psychosis (11 schizophrenia spectrum disorders and 17 bipolar disorder with psychotic features) were included. Metabolite (N-acetyl aspartate, choline, and creatine) and water T2 relaxation times were measured in the anterior corona radiata at 4T. Sleep was evaluated using the Pittsburgh Sleep Quality Index (PSQI).ResultsPSQI total score showed a moderate to strong positive correlation with water T2 (r = 0.64, p< 0.001). Linear regressions showed that this association was independent of the overall severity of depressive, manic, or psychotic symptoms. In our exploratory analysis, sleep disturbance was correlated with free water percentage, suggesting that increased extracellular water may be a mechanism underlying the association of disturbed sleep and prolonged water T2 relaxation.ConclusionOur results highlight the connection between poor sleep and WM abnormalities in psychotic disorders. Future research using objective sleep measures and neuroimaging techniques suitable to probe free water is needed to further our insight into this relationship. |
| format | Article |
| id | doaj-art-37ab9fd3d68a46e39f25852ef50dfa73 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-37ab9fd3d68a46e39f25852ef50dfa732025-01-07T06:44:20ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.14564351456435Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disordersUmit Haluk Yesilkaya0Umit Haluk Yesilkaya1Xi Chen2Xi Chen3Lauren Watford4Emma McCoy5Meltem Sen6Ilgin Genc7Fei Du8Fei Du9Dost Ongur10Dost Ongur11Cagri Yuksel12Cagri Yuksel13Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United StatesBakirkoy Training and Research Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, TürkiyeSchizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United StatesDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesSchizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United StatesSchizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United StatesSchizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United StatesSchizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United StatesSchizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United StatesDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesSchizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United StatesDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesSchizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA, United StatesDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesBackgroundPsychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear. Sleep disturbances are common in psychosis, and emerging evidence suggests that sleep plays a critical role in WM physiology. Therefore, it is plausible that sleep disturbances are associated with impaired WM integrity in these disorders. To test this hypothesis, we examined the association of self-reported sleep disturbances with WM transverse (T2) relaxation times in a cross-diagnostic sample of patients with psychosis.MethodsA total of 28 patients with psychosis (11 schizophrenia spectrum disorders and 17 bipolar disorder with psychotic features) were included. Metabolite (N-acetyl aspartate, choline, and creatine) and water T2 relaxation times were measured in the anterior corona radiata at 4T. Sleep was evaluated using the Pittsburgh Sleep Quality Index (PSQI).ResultsPSQI total score showed a moderate to strong positive correlation with water T2 (r = 0.64, p< 0.001). Linear regressions showed that this association was independent of the overall severity of depressive, manic, or psychotic symptoms. In our exploratory analysis, sleep disturbance was correlated with free water percentage, suggesting that increased extracellular water may be a mechanism underlying the association of disturbed sleep and prolonged water T2 relaxation.ConclusionOur results highlight the connection between poor sleep and WM abnormalities in psychotic disorders. Future research using objective sleep measures and neuroimaging techniques suitable to probe free water is needed to further our insight into this relationship.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1456435/fullsleepwhite matterT2 relaxationschizophreniabipolar disorderpsychosis |
| spellingShingle | Umit Haluk Yesilkaya Umit Haluk Yesilkaya Xi Chen Xi Chen Lauren Watford Emma McCoy Meltem Sen Ilgin Genc Fei Du Fei Du Dost Ongur Dost Ongur Cagri Yuksel Cagri Yuksel Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders Frontiers in Psychiatry sleep white matter T2 relaxation schizophrenia bipolar disorder psychosis |
| title | Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders |
| title_full | Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders |
| title_fullStr | Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders |
| title_full_unstemmed | Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders |
| title_short | Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders |
| title_sort | poor self reported sleep is associated with prolonged white matter t2 relaxation in psychotic disorders |
| topic | sleep white matter T2 relaxation schizophrenia bipolar disorder psychosis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1456435/full |
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