ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants

We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could se...

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Main Authors: Masato Hatta, Gloria P. Larson, Yasuko Hatta, Wei Wang, Nannan Jiang, Yu-Jin Jung, Li Wang, Xiaoyu Fan, Brenda M. Calderon, Gaston Bonenfant, Xudong Lin, Chenchen Feng, Dan Cui, Ginger Atteberry, Michael Currier, John Steel, David E. Wentworth, Bin Zhou
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2025-08-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/31/8/24-1844_article
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author Masato Hatta
Gloria P. Larson
Yasuko Hatta
Wei Wang
Nannan Jiang
Yu-Jin Jung
Li Wang
Xiaoyu Fan
Brenda M. Calderon
Gaston Bonenfant
Xudong Lin
Chenchen Feng
Dan Cui
Ginger Atteberry
Michael Currier
John Steel
David E. Wentworth
Bin Zhou
author_facet Masato Hatta
Gloria P. Larson
Yasuko Hatta
Wei Wang
Nannan Jiang
Yu-Jin Jung
Li Wang
Xiaoyu Fan
Brenda M. Calderon
Gaston Bonenfant
Xudong Lin
Chenchen Feng
Dan Cui
Ginger Atteberry
Michael Currier
John Steel
David E. Wentworth
Bin Zhou
author_sort Masato Hatta
collection DOAJ
description We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could serve as natural reservoirs or intermediate hosts for SARS-CoV-2.
format Article
id doaj-art-37a3dd92672049f584e561b6117ab6c4
institution DOAJ
issn 1080-6040
1080-6059
language English
publishDate 2025-08-01
publisher Centers for Disease Control and Prevention
record_format Article
series Emerging Infectious Diseases
spelling doaj-art-37a3dd92672049f584e561b6117ab6c42025-08-20T03:14:01ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-08-013181640164410.3201/eid3108.241844ACE2 Receptor Usage across Animal Species by SARS-CoV-2 VariantsMasato HattaGloria P. LarsonYasuko HattaWei WangNannan JiangYu-Jin JungLi WangXiaoyu FanBrenda M. CalderonGaston BonenfantXudong LinChenchen FengDan CuiGinger AtteberryMichael CurrierJohn SteelDavid E. WentworthBin Zhou We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could serve as natural reservoirs or intermediate hosts for SARS-CoV-2. https://wwwnc.cdc.gov/eid/article/31/8/24-1844_articleCOVID-19coronavirus diseaseSARS-CoV-2severe acute respiratory syndrome coronavirus 2virusesrespiratory infections
spellingShingle Masato Hatta
Gloria P. Larson
Yasuko Hatta
Wei Wang
Nannan Jiang
Yu-Jin Jung
Li Wang
Xiaoyu Fan
Brenda M. Calderon
Gaston Bonenfant
Xudong Lin
Chenchen Feng
Dan Cui
Ginger Atteberry
Michael Currier
John Steel
David E. Wentworth
Bin Zhou
ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
Emerging Infectious Diseases
COVID-19
coronavirus disease
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
viruses
respiratory infections
title ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
title_full ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
title_fullStr ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
title_full_unstemmed ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
title_short ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants
title_sort ace2 receptor usage across animal species by sars cov 2 variants
topic COVID-19
coronavirus disease
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
viruses
respiratory infections
url https://wwwnc.cdc.gov/eid/article/31/8/24-1844_article
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