Transcriptional regulatory networks underlying gene expression changes in Huntington's disease

Transcriptional regulatory networks underlying gene expression changes in Huntington's disease

Abstract Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD. We reconstructed a genome‐scale model for the target genes of 718 transcription factors (TFs) in the mouse striatum by in...

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Main Authors: Seth A Ament, Jocelynn R Pearl, Jeffrey P Cantle, Robert M Bragg, Peter J Skene, Sydney R Coffey, Dani E Bergey, Vanessa C Wheeler, Marcy E MacDonald, Nitin S Baliga, Jim Rosinski, Leroy E Hood, Jeffrey B Carroll, Nathan D Price
Format: Article
Language:English
Published: Springer Nature 2018-03-01
Series:Molecular Systems Biology
Subjects:
Huntington's disease
SMAD3
transcription factor
transcriptional regulatory networks
Online Access:https://doi.org/10.15252/msb.20167435
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