The implications of mutations in multiple genes associated with ethambutol resistance among multidrug-resistant tuberculosis isolates from China

The implications of mutations in multiple genes associated with ethambutol resistance among multidrug-resistant tuberculosis isolates from China

Abstract Objectives To assess the mutation effects of ethambutol (EMB) resistance-associated genes, including embCAB operon, ubiA, embR, and aftA, on the EMB resistance levels among multidrug-resistant tuberculosis (MDR-TB) isolates from China. Methods A total of 159 MDR-TB from China had their EMB...

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Main Authors: Ma-chao Li, Wei Wang, Tong-yang Xiao, Hai-can Liu, Shi-qiang Lin, Hao Hang, Xiang-long Bo, Xiao-tian Nan, Cheng Qian, Xue-ting Fan, Xiu-qin Zhao, Gui-lian Li, Kang-Lin Wan, Li-li Zhao
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Microbiology
Subjects:
Multidrug-resistant tuberculosis
Ethambutol
Resistance
Mutation
Online Access:https://doi.org/10.1186/s12866-025-03821-y
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