Clinical and laboratory validation and experience of picloxydine use in the treatment of neonatal dacryocystitis
Purpose: to improve the clinical and functional results of the treatment of dacryocystitis of newborns (DN) and to validate local antibiotic therapy of children with DN in laboratory conditions. Materials and methods. The study involved two groups of children with DN. Group 1 (275 eyes) consisted of...
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Real Time Ltd
2018-10-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/79 |
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| author | G. Z. Galeeva A. N. Samoylov |
| author_facet | G. Z. Galeeva A. N. Samoylov |
| author_sort | G. Z. Galeeva |
| collection | DOAJ |
| description | Purpose: to improve the clinical and functional results of the treatment of dacryocystitis of newborns (DN) and to validate local antibiotic therapy of children with DN in laboratory conditions. Materials and methods. The study involved two groups of children with DN. Group 1 (275 eyes) consisted of children treated as outpatients without taking account of the microbial spectrum of pathogens and their sensitivity to antibiotics. They had been prescribed the following medications: tobramycin (70.0 %), chloramphenicol (31.3 %) and tetracycline (17.2 %). Group 2 (118 eyes) consisted of children who received treatment based on the microbial spectrum of pathogens and their sensitivity to antibiotics. In this case, the treatment included picloxydine (Vitabact). In both groups, the children’s age was similar: 3.12 ± 0.18 months and 3.63 ±0.19 months, respectively (р > 0.05). Results. The microbial spectrum of DN pathogens is represented by 24 species of microorganisms and microbial associations (5.6 %). The major pathogens were: S. epidermidis (27.6 %), S. aureus (19.3 %) and S. pneumonia (8.0 %). The best sensitivity (94.1 %) was revealed to picloxydine (Vitabact). The treatment resulted in the recovery without probing the lacrimal tract in 6.1 % of group 1 patients and in 31.8 % of group 2 patients. Relapses requiring a re-probing of the lacrimal tract affected 12.3 % in group 1 and no patients in group 2. Conclusion. A two-stage DN treatment plan was developed and tested using etiologically validated antibacterial medications. The treatment resulted in the recovery of 31.8 % of children without probing the lacrimal tract, and prevention of DN relapses requiring re-probing // Russian Ophthalmological Journal, 2017; 1: 69-72. doi: 10.21516/2072-0076-2017-10-1-69-72. |
| format | Article |
| id | doaj-art-379de7edae1b4399a9ef0bd95a207b2a |
| institution | Kabale University |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2018-10-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-379de7edae1b4399a9ef0bd95a207b2a2025-08-20T03:39:45ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602018-10-01101697210.21516/2072-0076-2017-10-1-69-7279Clinical and laboratory validation and experience of picloxydine use in the treatment of neonatal dacryocystitisG. Z. Galeeva0A. N. Samoylov1Kazan State medical university, Kazan, RussiaKazan State medical university, Kazan, RussiaPurpose: to improve the clinical and functional results of the treatment of dacryocystitis of newborns (DN) and to validate local antibiotic therapy of children with DN in laboratory conditions. Materials and methods. The study involved two groups of children with DN. Group 1 (275 eyes) consisted of children treated as outpatients without taking account of the microbial spectrum of pathogens and their sensitivity to antibiotics. They had been prescribed the following medications: tobramycin (70.0 %), chloramphenicol (31.3 %) and tetracycline (17.2 %). Group 2 (118 eyes) consisted of children who received treatment based on the microbial spectrum of pathogens and their sensitivity to antibiotics. In this case, the treatment included picloxydine (Vitabact). In both groups, the children’s age was similar: 3.12 ± 0.18 months and 3.63 ±0.19 months, respectively (р > 0.05). Results. The microbial spectrum of DN pathogens is represented by 24 species of microorganisms and microbial associations (5.6 %). The major pathogens were: S. epidermidis (27.6 %), S. aureus (19.3 %) and S. pneumonia (8.0 %). The best sensitivity (94.1 %) was revealed to picloxydine (Vitabact). The treatment resulted in the recovery without probing the lacrimal tract in 6.1 % of group 1 patients and in 31.8 % of group 2 patients. Relapses requiring a re-probing of the lacrimal tract affected 12.3 % in group 1 and no patients in group 2. Conclusion. A two-stage DN treatment plan was developed and tested using etiologically validated antibacterial medications. The treatment resulted in the recovery of 31.8 % of children without probing the lacrimal tract, and prevention of DN relapses requiring re-probing // Russian Ophthalmological Journal, 2017; 1: 69-72. doi: 10.21516/2072-0076-2017-10-1-69-72.https://roj.igb.ru/jour/article/view/79дакриоцистит новорожденныхзондирование слезоотводящих путейвитабактпиклоксидинdacryocystitis of newbornslacrimal tract probingvitabactpicloxydine |
| spellingShingle | G. Z. Galeeva A. N. Samoylov Clinical and laboratory validation and experience of picloxydine use in the treatment of neonatal dacryocystitis Российский офтальмологический журнал дакриоцистит новорожденных зондирование слезоотводящих путей витабакт пиклоксидин dacryocystitis of newborns lacrimal tract probing vitabact picloxydine |
| title | Clinical and laboratory validation and experience of picloxydine use in the treatment of neonatal dacryocystitis |
| title_full | Clinical and laboratory validation and experience of picloxydine use in the treatment of neonatal dacryocystitis |
| title_fullStr | Clinical and laboratory validation and experience of picloxydine use in the treatment of neonatal dacryocystitis |
| title_full_unstemmed | Clinical and laboratory validation and experience of picloxydine use in the treatment of neonatal dacryocystitis |
| title_short | Clinical and laboratory validation and experience of picloxydine use in the treatment of neonatal dacryocystitis |
| title_sort | clinical and laboratory validation and experience of picloxydine use in the treatment of neonatal dacryocystitis |
| topic | дакриоцистит новорожденных зондирование слезоотводящих путей витабакт пиклоксидин dacryocystitis of newborns lacrimal tract probing vitabact picloxydine |
| url | https://roj.igb.ru/jour/article/view/79 |
| work_keys_str_mv | AT gzgaleeva clinicalandlaboratoryvalidationandexperienceofpicloxydineuseinthetreatmentofneonataldacryocystitis AT ansamoylov clinicalandlaboratoryvalidationandexperienceofpicloxydineuseinthetreatmentofneonataldacryocystitis |