Nonalcoholic Fatty Hepatitis: An Important Clinical Condition
The entity fatty hepatitis is defined and the literature characterizing the clinical settings in which it develops is reviewed. The pathogenesis is discussed with emphasis on the common denominators shared by the various clinical conditions with which it is associated. The roles of alcohol, obesity...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/601524 |
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| _version_ | 1832560472329551872 |
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| author | Samuel W. French Leslie B. Eidus J. Freeman |
| author_facet | Samuel W. French Leslie B. Eidus J. Freeman |
| author_sort | Samuel W. French |
| collection | DOAJ |
| description | The entity fatty hepatitis is defined and the literature characterizing
the clinical settings in which it develops is reviewed. The pathogenesis is
discussed with emphasis on the common denominators shared by the various
clinical conditions with which it is associated. The roles of alcohol, obesity and
type II diabetes are stressed where inhibition of fatty acid oxidation by the liver is
the basic defect in metabolism leading to fatty change, balloon degeneration and
Mallory body formation. It is concluded that this important entity is more common
than is generally appreciated. |
| format | Article |
| id | doaj-art-37993afd1db142728d4eb4cd70493434 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1989-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-37993afd1db142728d4eb4cd704934342025-02-03T01:27:27ZengWileyCanadian Journal of Gastroenterology0835-79001989-01-013518919710.1155/1989/601524Nonalcoholic Fatty Hepatitis: An Important Clinical ConditionSamuel W. French0Leslie B. Eidus1J. Freeman2Departments of Pathology and Surgery, University of Ottawa, Department of Laboratory Medicine, Ottawa General Hospital, Ottawa, Ontario, CanadaDepartments of Pathology and Surgery, University of Ottawa, Department of Laboratory Medicine, Ottawa General Hospital, Ottawa, Ontario, CanadaDepartments of Pathology and Surgery, University of Ottawa, Department of Laboratory Medicine, Ottawa General Hospital, Ottawa, Ontario, CanadaThe entity fatty hepatitis is defined and the literature characterizing the clinical settings in which it develops is reviewed. The pathogenesis is discussed with emphasis on the common denominators shared by the various clinical conditions with which it is associated. The roles of alcohol, obesity and type II diabetes are stressed where inhibition of fatty acid oxidation by the liver is the basic defect in metabolism leading to fatty change, balloon degeneration and Mallory body formation. It is concluded that this important entity is more common than is generally appreciated.http://dx.doi.org/10.1155/1989/601524 |
| spellingShingle | Samuel W. French Leslie B. Eidus J. Freeman Nonalcoholic Fatty Hepatitis: An Important Clinical Condition Canadian Journal of Gastroenterology |
| title | Nonalcoholic Fatty Hepatitis: An Important Clinical Condition |
| title_full | Nonalcoholic Fatty Hepatitis: An Important Clinical Condition |
| title_fullStr | Nonalcoholic Fatty Hepatitis: An Important Clinical Condition |
| title_full_unstemmed | Nonalcoholic Fatty Hepatitis: An Important Clinical Condition |
| title_short | Nonalcoholic Fatty Hepatitis: An Important Clinical Condition |
| title_sort | nonalcoholic fatty hepatitis an important clinical condition |
| url | http://dx.doi.org/10.1155/1989/601524 |
| work_keys_str_mv | AT samuelwfrench nonalcoholicfattyhepatitisanimportantclinicalcondition AT lesliebeidus nonalcoholicfattyhepatitisanimportantclinicalcondition AT jfreeman nonalcoholicfattyhepatitisanimportantclinicalcondition |