Combined effects of metformin and coenzyme Q10 on doxorubicin-induced cardiotoxicity in male wistar rats

Combined effects of metformin and coenzyme Q10 on doxorubicin-induced cardiotoxicity in male wistar rats

Abstract Doxorubicin (DOX) is an effective anticancer drug, but its clinical application is limited due to its severe adverse effects on multiple organs and tissues, particularly cardiotoxicity. Studies suggest that metformin and Coenzyme Q10 (CoQ10) may help reduce DOX-induced cardiotoxicity. This...

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Bibliographic Details
Main Authors: Faraz Mahdizadeh, Aliakbar Fazaeli, Shiva Rahimi, Masoud Ojarudi, Pouria Sobhi, Mohammad Bahrami, Lotfollah Rezagholizadeh
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Metformin
Coenzyme Q10
Doxorubicin
Cardiotoxicity
Cardioprotection
Online Access:https://doi.org/10.1038/s41598-025-07576-4
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