The influence of sleep duration on patients with coronary artery disease: a four-year observational study
BackgroundCoronary artery disease (CAD) is highly prevalent and fatal worldwide. In China, particularly in the southwest region, the association between CAD and sleep duration remains insufficiently understood. This study aims to investigate outcomes among CAD patients with varying sleep duration.Me...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
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| author | Runfeng Ma Ruoyu Wang Bingqian Wang Zihan Tang Tian Qiu Yiduo Lu Gang Liu |
| author_facet | Runfeng Ma Ruoyu Wang Bingqian Wang Zihan Tang Tian Qiu Yiduo Lu Gang Liu |
| author_sort | Runfeng Ma |
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| description | BackgroundCoronary artery disease (CAD) is highly prevalent and fatal worldwide. In China, particularly in the southwest region, the association between CAD and sleep duration remains insufficiently understood. This study aims to investigate outcomes among CAD patients with varying sleep duration.MethodsIn a Southwest Chinese cohort, patients with CAD were categorized into three sleep duration groups: <6 hours, 6–8 hours, and >8 hours. Over a four-year follow-up, the endpoint including new-onset myocardial infarction and CAD-related deaths was recorded. The Fine-Gray model was employed to evaluate the estimated marginal occurrence probability of the target event. Additionally, Kaplan-Meier estimation and Cox regression analysis were conducted to further investigate the association between sleep duration and outcomes.ResultsThe study enrolled 816 residents with CAD, who had an average age of 69.2 ± 8.3 years old, of whom 40.2% were male. Across the three sleep duration groups (6-8h, <6h, and >8h), the hazard ratios (HRs) with 95% confidence interval for new-onset myocardial infarction were: 1.00 (reference), 2.67 (1.57-4.55) (P < 0.001), and 0.98 (0.30-3.21) (P=0.970). For CAD-related mortality, the HRs were: 1.00 (reference), 5.20 (2.53-10.68) (P < 0.001), and 5.02 (1.59-15.80) (P=0.006). This trend was consistently observed in both the Fine-Gray model and subgroup analyses.ConclusionsBoth short (<6 hours/day) and long (>8 hours/day) sleep duration were linked to an elevated risk of cardiac mortality among CAD patients in Southwest China. Short sleep duration was also found to be associated with high myocardial infarction risk. |
| format | Article |
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| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-378b4ac4e8ed44e1a3fdf9956d1e025a2025-08-20T02:11:25ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.15558801555880The influence of sleep duration on patients with coronary artery disease: a four-year observational studyRunfeng Ma0Ruoyu Wang1Bingqian Wang2Zihan Tang3Tian Qiu4Yiduo Lu5Gang Liu6International Medical College, Chongqing Medical University, Chongqing, ChinaInternational Medical College, Chongqing Medical University, Chongqing, ChinaInternational Medical College, Chongqing Medical University, Chongqing, ChinaInternational Medical College, Chongqing Medical University, Chongqing, ChinaInternational Medical College, Chongqing Medical University, Chongqing, ChinaCollege of Basic Medical Sciences, Naval Medical University, Shanghai, ChinaDepartment of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackgroundCoronary artery disease (CAD) is highly prevalent and fatal worldwide. In China, particularly in the southwest region, the association between CAD and sleep duration remains insufficiently understood. This study aims to investigate outcomes among CAD patients with varying sleep duration.MethodsIn a Southwest Chinese cohort, patients with CAD were categorized into three sleep duration groups: <6 hours, 6–8 hours, and >8 hours. Over a four-year follow-up, the endpoint including new-onset myocardial infarction and CAD-related deaths was recorded. The Fine-Gray model was employed to evaluate the estimated marginal occurrence probability of the target event. Additionally, Kaplan-Meier estimation and Cox regression analysis were conducted to further investigate the association between sleep duration and outcomes.ResultsThe study enrolled 816 residents with CAD, who had an average age of 69.2 ± 8.3 years old, of whom 40.2% were male. Across the three sleep duration groups (6-8h, <6h, and >8h), the hazard ratios (HRs) with 95% confidence interval for new-onset myocardial infarction were: 1.00 (reference), 2.67 (1.57-4.55) (P < 0.001), and 0.98 (0.30-3.21) (P=0.970). For CAD-related mortality, the HRs were: 1.00 (reference), 5.20 (2.53-10.68) (P < 0.001), and 5.02 (1.59-15.80) (P=0.006). This trend was consistently observed in both the Fine-Gray model and subgroup analyses.ConclusionsBoth short (<6 hours/day) and long (>8 hours/day) sleep duration were linked to an elevated risk of cardiac mortality among CAD patients in Southwest China. Short sleep duration was also found to be associated with high myocardial infarction risk.https://www.frontiersin.org/articles/10.3389/fendo.2025.1555880/fullsleep durationcoronary artery diseaseCAD-related mortalitymyocardial infarctionSouthwest China |
| spellingShingle | Runfeng Ma Ruoyu Wang Bingqian Wang Zihan Tang Tian Qiu Yiduo Lu Gang Liu The influence of sleep duration on patients with coronary artery disease: a four-year observational study Frontiers in Endocrinology sleep duration coronary artery disease CAD-related mortality myocardial infarction Southwest China |
| title | The influence of sleep duration on patients with coronary artery disease: a four-year observational study |
| title_full | The influence of sleep duration on patients with coronary artery disease: a four-year observational study |
| title_fullStr | The influence of sleep duration on patients with coronary artery disease: a four-year observational study |
| title_full_unstemmed | The influence of sleep duration on patients with coronary artery disease: a four-year observational study |
| title_short | The influence of sleep duration on patients with coronary artery disease: a four-year observational study |
| title_sort | influence of sleep duration on patients with coronary artery disease a four year observational study |
| topic | sleep duration coronary artery disease CAD-related mortality myocardial infarction Southwest China |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1555880/full |
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