An overview of structurally diversified anticonvulsant agents
There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions. Despite the availability of all these new and old approaches, seizure is particularly difficult to manage. The quest for new antiepileptic mol...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2019-0023 |
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| author | Al-Otaibi Faisal |
| author_facet | Al-Otaibi Faisal |
| author_sort | Al-Otaibi Faisal |
| collection | DOAJ |
| description | There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions. Despite the availability of all these new and old approaches, seizure is particularly difficult to manage. The quest for new antiepileptic molecules with more specificity and less CNS toxicity continues for medicinal chemists until a new and ideal drug arrives. This review covers new antiseizure molecules of different chemical classes, the exact mode of action of which is still unidentified. Newer agents include sulfonamides, thiadiazoles, semi- and thiosemicarbazones, pyrrolidine-2,5-diones, imidazoles, benzothiazoles and amino acid deriva tives. These new chemical entities can be useful for the design and development of forthcoming antiseizure agents. |
| format | Article |
| id | doaj-art-3788bf49b96a4ee6bd99b6d8f256c158 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-3788bf49b96a4ee6bd99b6d8f256c1582025-02-02T23:02:22ZengSciendoActa Pharmaceutica1846-95582019-09-0169332134410.2478/acph-2019-0023acph-2019-0023An overview of structurally diversified anticonvulsant agentsAl-Otaibi Faisal0Department of Clinical Pharmacy College of Pharmacy, Shaqra University, Al-dawadmi P. O. BOX 33, Saudi ArabiaThere are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions. Despite the availability of all these new and old approaches, seizure is particularly difficult to manage. The quest for new antiepileptic molecules with more specificity and less CNS toxicity continues for medicinal chemists until a new and ideal drug arrives. This review covers new antiseizure molecules of different chemical classes, the exact mode of action of which is still unidentified. Newer agents include sulfonamides, thiadiazoles, semi- and thiosemicarbazones, pyrrolidine-2,5-diones, imidazoles, benzothiazoles and amino acid deriva tives. These new chemical entities can be useful for the design and development of forthcoming antiseizure agents.https://doi.org/10.2478/acph-2019-0023antiepileptic agentssulfonamidesimidazolesthiadiazolesbenzothiazolesamino acid derivatives |
| spellingShingle | Al-Otaibi Faisal An overview of structurally diversified anticonvulsant agents Acta Pharmaceutica antiepileptic agents sulfonamides imidazoles thiadiazoles benzothiazoles amino acid derivatives |
| title | An overview of structurally diversified anticonvulsant agents |
| title_full | An overview of structurally diversified anticonvulsant agents |
| title_fullStr | An overview of structurally diversified anticonvulsant agents |
| title_full_unstemmed | An overview of structurally diversified anticonvulsant agents |
| title_short | An overview of structurally diversified anticonvulsant agents |
| title_sort | overview of structurally diversified anticonvulsant agents |
| topic | antiepileptic agents sulfonamides imidazoles thiadiazoles benzothiazoles amino acid derivatives |
| url | https://doi.org/10.2478/acph-2019-0023 |
| work_keys_str_mv | AT alotaibifaisal anoverviewofstructurallydiversifiedanticonvulsantagents AT alotaibifaisal overviewofstructurallydiversifiedanticonvulsantagents |