Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment

Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment

BackgroundThere has been limited success of cancer immunotherapies in the treatment of ovarian cancer (OvCa) to date, largely due to the immunosuppressive tumour microenvironment (TME). Tumour-associated macrophages (TAMs) are a major component of both the primary tumour and malignant ascites, promo...

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Bibliographic Details
Main Authors: Victoria A. Jennings, Reah Rumbold-Hall, Gemma Migneco, Tyler Barr, Katrina Reilly, Nicola Ingram, Isabelle St Hilare, Samuel Heaton, Noura Alzamel, David Jackson, Christy Ralph, Susan Banerjee, Iain McNeish, John C. Bell, Alan A. Melcher, Carolina Ilkow, Graham P. Cook, Fiona Errington-Mais
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
oncolytic virus
miRNA
tumour associated macrophage
tumour microenvironment
anti-tumour immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500570/full
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