A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature Review
The most common organisms isolated from pediatric catheter-related bloodstream infections (CRBSIs) are Gram-positive cocci, such as coagulase-negative staphylococci and Staphylococcus aureus. There are few formal reports of Brevibacterium casei infection and even fewer reports of CRBSI due to this G...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2021/6691569 |
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| author | Fumihiro Ochi Hisamichi Tauchi Kyoko Moritani Shinobu Murakami Hitoshi Miyamoto Mayo Ueda Kozo Nagai Minenori Eguchi-Ishimae Mariko Eguchi |
| author_facet | Fumihiro Ochi Hisamichi Tauchi Kyoko Moritani Shinobu Murakami Hitoshi Miyamoto Mayo Ueda Kozo Nagai Minenori Eguchi-Ishimae Mariko Eguchi |
| author_sort | Fumihiro Ochi |
| collection | DOAJ |
| description | The most common organisms isolated from pediatric catheter-related bloodstream infections (CRBSIs) are Gram-positive cocci, such as coagulase-negative staphylococci and Staphylococcus aureus. There are few formal reports of Brevibacterium casei infection and even fewer reports of CRBSI due to this Gram-positive rod. Here we report the first case of CRBSI due to B. casei in an 8-year-old girl with acute myeloid leukemia in Japan. The isolate exhibited decreased susceptibility to ß-lactam antibiotics. Antimicrobial therapy with meropenem and vancomycin, in addition to the removal of central venous catheter line, consequently led to a significant clinical improvement of the patient’s symptoms. A literature review found available clinical courses in 16 cases (4 pediatric cases including our case) of B. casei infection. Our case and those in literature suggested that B. casei infection often occurs in patients with indwelling central venous catheters; the literature review further suggested that removal of central venous catheters is required in most cases. Special attention should be paid to the detection of opportunistic infections due to Brevibacterium spp. in immunocompromized children who are using a central venous catheter. |
| format | Article |
| id | doaj-art-3781d8a574314e98a7898b4e9725809d |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-3781d8a574314e98a7898b4e9725809d2025-02-03T00:58:55ZengWileyCase Reports in Pediatrics2090-68032090-68112021-01-01202110.1155/2021/66915696691569A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature ReviewFumihiro Ochi0Hisamichi Tauchi1Kyoko Moritani2Shinobu Murakami3Hitoshi Miyamoto4Mayo Ueda5Kozo Nagai6Minenori Eguchi-Ishimae7Mariko Eguchi8Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanClinical Laboratory Division, Ehime University Hospital, Toon, Ehime 791-0295, JapanClinical Laboratory Division, Ehime University Hospital, Toon, Ehime 791-0295, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanThe most common organisms isolated from pediatric catheter-related bloodstream infections (CRBSIs) are Gram-positive cocci, such as coagulase-negative staphylococci and Staphylococcus aureus. There are few formal reports of Brevibacterium casei infection and even fewer reports of CRBSI due to this Gram-positive rod. Here we report the first case of CRBSI due to B. casei in an 8-year-old girl with acute myeloid leukemia in Japan. The isolate exhibited decreased susceptibility to ß-lactam antibiotics. Antimicrobial therapy with meropenem and vancomycin, in addition to the removal of central venous catheter line, consequently led to a significant clinical improvement of the patient’s symptoms. A literature review found available clinical courses in 16 cases (4 pediatric cases including our case) of B. casei infection. Our case and those in literature suggested that B. casei infection often occurs in patients with indwelling central venous catheters; the literature review further suggested that removal of central venous catheters is required in most cases. Special attention should be paid to the detection of opportunistic infections due to Brevibacterium spp. in immunocompromized children who are using a central venous catheter.http://dx.doi.org/10.1155/2021/6691569 |
| spellingShingle | Fumihiro Ochi Hisamichi Tauchi Kyoko Moritani Shinobu Murakami Hitoshi Miyamoto Mayo Ueda Kozo Nagai Minenori Eguchi-Ishimae Mariko Eguchi A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature Review Case Reports in Pediatrics |
| title | A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature Review |
| title_full | A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature Review |
| title_fullStr | A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature Review |
| title_full_unstemmed | A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature Review |
| title_short | A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature Review |
| title_sort | catheter related bloodstream infection by brevibacterium casei in a child with acute myeloid leukemia case report and literature review |
| url | http://dx.doi.org/10.1155/2021/6691569 |
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