Repurposing COVID-19 Compounds (via MMV COVID Box): Almitrine and Bortezomib Induce Programmed Cell Death in <i>Trypanosoma cruzi</i>

Repurposing COVID-19 Compounds (via MMV COVID Box): Almitrine and Bortezomib Induce Programmed Cell Death in <i>Trypanosoma cruzi</i>

Chagas disease, caused by the protozoan <i>Trypanosoma cruzi</i>, affects millions globally, with limited treatment options available. Current therapies, such as benznidazole and nifurtimox, present challenges, including their toxicity, side effects, and inefficacy in the chronic phase....

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Bibliographic Details
Main Authors: Carlos J. Bethencourt-Estrella, Atteneri López-Arencibia, Jacob Lorenzo-Morales, José E. Piñero
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pathogens
Subjects:
<i>Trypanosoma cruzi</i>
chemotherapy
apoptosis
COVID Box
MMV
Online Access:https://www.mdpi.com/2076-0817/14/2/127
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