Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats

This paper shows a new finding about the decrease of relaxative response to loperamide in prostate of spontaneously hypertensive rats (SHR) as compare to normal rats (WKY). Authors demonstrated the reduction of ATP-sensitive potassium channels is resposible for this change using immunoblotting analy...

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Main Authors: Liang-Ming Lee, Chih-Cheng Lu, Hsien-Hui Chung, Juei-Tang Cheng
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2012/941685
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author Liang-Ming Lee
Chih-Cheng Lu
Hsien-Hui Chung
Juei-Tang Cheng
author_facet Liang-Ming Lee
Chih-Cheng Lu
Hsien-Hui Chung
Juei-Tang Cheng
author_sort Liang-Ming Lee
collection DOAJ
description This paper shows a new finding about the decrease of relaxative response to loperamide in prostate of spontaneously hypertensive rats (SHR) as compare to normal rats (WKY). Authors demonstrated the reduction of ATP-sensitive potassium channels is resposible for this change using immunoblotting analysis and the decrease of action induced by diazoxide. This view is not mentioned before and is the first one reporting this result.
format Article
id doaj-art-3777ee8653744a4187c39f9f3a04e862
institution DOAJ
issn 1537-744X
language English
publishDate 2012-01-01
publisher Wiley
record_format Article
series The Scientific World Journal
spelling doaj-art-3777ee8653744a4187c39f9f3a04e8622025-08-20T03:20:30ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/941685941685Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive RatsLiang-Ming Lee0Chih-Cheng Lu1Hsien-Hui Chung2Juei-Tang Cheng3Department of Urology, College of Medicine, Wan-Fang Hospital, Taipei Medical University, Wang-Fang, Taipei 110, TaiwanDepartment of Surgery, Chi Mei Medical Center Liouying, LiouYing, Tainan 736, TaiwanInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanThis paper shows a new finding about the decrease of relaxative response to loperamide in prostate of spontaneously hypertensive rats (SHR) as compare to normal rats (WKY). Authors demonstrated the reduction of ATP-sensitive potassium channels is resposible for this change using immunoblotting analysis and the decrease of action induced by diazoxide. This view is not mentioned before and is the first one reporting this result.http://dx.doi.org/10.1100/2012/941685
spellingShingle Liang-Ming Lee
Chih-Cheng Lu
Hsien-Hui Chung
Juei-Tang Cheng
Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats
The Scientific World Journal
title Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats
title_full Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats
title_fullStr Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats
title_full_unstemmed Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats
title_short Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats
title_sort prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats
url http://dx.doi.org/10.1100/2012/941685
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AT chihchenglu prostaticrelaxationinducedbyloperamideisreducedinspontaneouslyhypertensiverats
AT hsienhuichung prostaticrelaxationinducedbyloperamideisreducedinspontaneouslyhypertensiverats
AT jueitangcheng prostaticrelaxationinducedbyloperamideisreducedinspontaneouslyhypertensiverats