A pH-dependent direct sulfhydrylation pathway is required for the pathogenesis of Mycobacterium tuberculosis

A pH-dependent direct sulfhydrylation pathway is required for the pathogenesis of Mycobacterium tuberculosis

Abstract Methionine is essential for the growth and survival of Mycobacterium tuberculosis (M. tuberculosis), however, the canonical transsulfuration pathway involved in the biosynthesis of methionine is dispensable, suggesting redundancy. This study explores the presence of an ortholog of O-succiny...

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Main Authors: Vaibhav Kumar Nain, Vishawjeet Barik, Manitosh Pandey, Mohit Pareek, Taruna Sharma, Rahul Pal, Shaifali Tyagi, Manish Bajpai, Prabhanjan Dwivedi, Bhishma Narayan Panda, Yashwant Kumar, Shailendra Asthana, Amit Kumar Pandey
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08051-6
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