Parthenolide: pioneering new frontiers in hematological malignancies
Hematological malignancies are the fifth most prevalent cancer category in developed countries, presenting significant treatment challenges. The side effects of chemotherapy and its non-selective nature have led researchers to explore combination therapies to enhance efficacy and improve patient out...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1534686/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850150582121136128 |
|---|---|
| author | Elmira Zarei Ayda Zarei Azadeh Omidkhoda |
| author_facet | Elmira Zarei Ayda Zarei Azadeh Omidkhoda |
| author_sort | Elmira Zarei |
| collection | DOAJ |
| description | Hematological malignancies are the fifth most prevalent cancer category in developed countries, presenting significant treatment challenges. The side effects of chemotherapy and its non-selective nature have led researchers to explore combination therapies to enhance efficacy and improve patient outcomes. Parthenolide (PTL) emerges as a promising candidate, being the first small molecule identified for its selective action against leukemic stem cells. This article provides an overview of PTL’s effects and its potential as a complementary treatment for hematological malignancies. A systematic search in PubMed, Scopus, Embase and Web of Science identified relevant studies using keywords and MeSH terms. Peer-reviewed studies examining PTL’s mechanisms and therapeutic potential were included, while non-hematological studies and those lacking rigor were excluded. PTL targets key signaling pathways to combat malignancy, inhibiting NF-κB and signal transducer and STAT3, promoting ROS production, and activating p53. These mechanisms contribute to its effectiveness in treating hematological malignancies. Approaches incorporating PTL or its derivatives show promise in increasing leukemic cell sensitivity to existing therapies and reducing resistance likelihood. Additionally, studies indicate that other drugs can synergistically enhance PTL’s ability to eliminate leukemic cells. In conclusion, PTL represents a promising avenue for improving therapeutic outcomes in hematological malignancies, warranting further investigation into its mechanisms and potential in combination therapies. |
| format | Article |
| id | doaj-art-376e7aa96c5b4f0db3708326ce2ff46a |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-376e7aa96c5b4f0db3708326ce2ff46a2025-08-20T02:26:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15346861534686Parthenolide: pioneering new frontiers in hematological malignanciesElmira Zarei0Ayda Zarei1Azadeh Omidkhoda2Department of Hematology and Blood Banking, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, IranDepartment of Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Hematology and Blood Banking, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, IranHematological malignancies are the fifth most prevalent cancer category in developed countries, presenting significant treatment challenges. The side effects of chemotherapy and its non-selective nature have led researchers to explore combination therapies to enhance efficacy and improve patient outcomes. Parthenolide (PTL) emerges as a promising candidate, being the first small molecule identified for its selective action against leukemic stem cells. This article provides an overview of PTL’s effects and its potential as a complementary treatment for hematological malignancies. A systematic search in PubMed, Scopus, Embase and Web of Science identified relevant studies using keywords and MeSH terms. Peer-reviewed studies examining PTL’s mechanisms and therapeutic potential were included, while non-hematological studies and those lacking rigor were excluded. PTL targets key signaling pathways to combat malignancy, inhibiting NF-κB and signal transducer and STAT3, promoting ROS production, and activating p53. These mechanisms contribute to its effectiveness in treating hematological malignancies. Approaches incorporating PTL or its derivatives show promise in increasing leukemic cell sensitivity to existing therapies and reducing resistance likelihood. Additionally, studies indicate that other drugs can synergistically enhance PTL’s ability to eliminate leukemic cells. In conclusion, PTL represents a promising avenue for improving therapeutic outcomes in hematological malignancies, warranting further investigation into its mechanisms and potential in combination therapies.https://www.frontiersin.org/articles/10.3389/fphar.2025.1534686/fullhematological malignancyparthenolideherbal extractleukemiaNF-kB |
| spellingShingle | Elmira Zarei Ayda Zarei Azadeh Omidkhoda Parthenolide: pioneering new frontiers in hematological malignancies Frontiers in Pharmacology hematological malignancy parthenolide herbal extract leukemia NF-kB |
| title | Parthenolide: pioneering new frontiers in hematological malignancies |
| title_full | Parthenolide: pioneering new frontiers in hematological malignancies |
| title_fullStr | Parthenolide: pioneering new frontiers in hematological malignancies |
| title_full_unstemmed | Parthenolide: pioneering new frontiers in hematological malignancies |
| title_short | Parthenolide: pioneering new frontiers in hematological malignancies |
| title_sort | parthenolide pioneering new frontiers in hematological malignancies |
| topic | hematological malignancy parthenolide herbal extract leukemia NF-kB |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1534686/full |
| work_keys_str_mv | AT elmirazarei parthenolidepioneeringnewfrontiersinhematologicalmalignancies AT aydazarei parthenolidepioneeringnewfrontiersinhematologicalmalignancies AT azadehomidkhoda parthenolidepioneeringnewfrontiersinhematologicalmalignancies |