Organoids for tissue repair and regeneration
Tissue damage and dysfunction are common consequences of various diseases and trauma, severely impacting patients' quality of life. Organoids, three-dimensional cell clusters formed through the self-organization of stem cells, not only recapitulate the developmental processes of native tissues...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425005836 |
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| author | Biao Yu Dongyang Zhou Fuxiao Wang Xiao Chen Mengmeng Li Jiacan Su |
| author_facet | Biao Yu Dongyang Zhou Fuxiao Wang Xiao Chen Mengmeng Li Jiacan Su |
| author_sort | Biao Yu |
| collection | DOAJ |
| description | Tissue damage and dysfunction are common consequences of various diseases and trauma, severely impacting patients' quality of life. Organoids, three-dimensional cell clusters formed through the self-organization of stem cells, not only recapitulate the developmental processes of native tissues but also exhibit remarkable plasticity and long-term expansion capabilities, demonstrating potential to overcome limitations of conventional therapeutic approaches. Particularly in addressing challenges such as immune rejection and regenerative efficiency, organoid technology has shown distinct advantages. This review summarizes the applications of organoids in tissue repair, including the biological principles and cultivation strategies of organoid culture, as well as their specific applications and preclinical research progress across diverse tissues (e.g., brain, liver, intestine, bone). Additionally, it discusses current challenges in organoid technology, such as large-scale production, heterogeneity control, and clinical translation, while outlining future development directions. |
| format | Article |
| id | doaj-art-3769fd888aeb4430b5e1bad59e45972c |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-3769fd888aeb4430b5e1bad59e45972c2025-08-20T03:24:07ZengElsevierMaterials Today Bio2590-00642025-08-013310201310.1016/j.mtbio.2025.102013Organoids for tissue repair and regenerationBiao Yu0Dongyang Zhou1Fuxiao Wang2Xiao Chen3Mengmeng Li4Jiacan Su5MedEng-X Institutes, Shanghai University, Shanghai, 200444, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; School of Medicine, Shanghai University, Shanghai, 200444, China; Graduate College for Engineers, Shanghai University, Shanghai, 200444, ChinaMedEng-X Institutes, Shanghai University, Shanghai, 200444, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; Wenzhou Institute of Shanghai University, Wenzhou, 325000, ChinaMedEng-X Institutes, Shanghai University, Shanghai, 200444, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; School of Medicine, Shanghai University, Shanghai, 200444, ChinaDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Corresponding author.MedEng-X Institutes, Shanghai University, Shanghai, 200444, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; Corresponding author. Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.MedEng-X Institutes, Shanghai University, Shanghai, 200444, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Corresponding author. MedEng-X Institutes, Shanghai University, Shanghai, 200444, China.Tissue damage and dysfunction are common consequences of various diseases and trauma, severely impacting patients' quality of life. Organoids, three-dimensional cell clusters formed through the self-organization of stem cells, not only recapitulate the developmental processes of native tissues but also exhibit remarkable plasticity and long-term expansion capabilities, demonstrating potential to overcome limitations of conventional therapeutic approaches. Particularly in addressing challenges such as immune rejection and regenerative efficiency, organoid technology has shown distinct advantages. This review summarizes the applications of organoids in tissue repair, including the biological principles and cultivation strategies of organoid culture, as well as their specific applications and preclinical research progress across diverse tissues (e.g., brain, liver, intestine, bone). Additionally, it discusses current challenges in organoid technology, such as large-scale production, heterogeneity control, and clinical translation, while outlining future development directions.http://www.sciencedirect.com/science/article/pii/S2590006425005836OrganoidsOrganoid derivativesStem cellsTissue repairRegenerative medicine |
| spellingShingle | Biao Yu Dongyang Zhou Fuxiao Wang Xiao Chen Mengmeng Li Jiacan Su Organoids for tissue repair and regeneration Materials Today Bio Organoids Organoid derivatives Stem cells Tissue repair Regenerative medicine |
| title | Organoids for tissue repair and regeneration |
| title_full | Organoids for tissue repair and regeneration |
| title_fullStr | Organoids for tissue repair and regeneration |
| title_full_unstemmed | Organoids for tissue repair and regeneration |
| title_short | Organoids for tissue repair and regeneration |
| title_sort | organoids for tissue repair and regeneration |
| topic | Organoids Organoid derivatives Stem cells Tissue repair Regenerative medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425005836 |
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