The changing molecular epidemiology of HIV-1 in Liangshan prefecture, China, in 2021–2023
IntroductionLiangshan Prefecture is one of the areas in China most severely affected by human immunodeficiency virus (HIV), but little is known about the molecular epidemiology of HIV-1 in this area. We aimed to analyze the distribution of HIV-1 genetic variants in Liangshan Prefecture in recent yea...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1520864/full |
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| author | Rong Pei Rong Pei Ling Su Chunnong Jike Gang Yu Ju Wang Lin Xiao Yubing Wang Maogang Shen Chang Zhou Jiayi Liao Yulian Zhang Yifei Zheng Joris Hemelaar |
| author_facet | Rong Pei Rong Pei Ling Su Chunnong Jike Gang Yu Ju Wang Lin Xiao Yubing Wang Maogang Shen Chang Zhou Jiayi Liao Yulian Zhang Yifei Zheng Joris Hemelaar |
| author_sort | Rong Pei |
| collection | DOAJ |
| description | IntroductionLiangshan Prefecture is one of the areas in China most severely affected by human immunodeficiency virus (HIV), but little is known about the molecular epidemiology of HIV-1 in this area. We aimed to analyze the distribution of HIV-1 genetic variants in Liangshan Prefecture in recent years.Methods8,523 blood samples were collected from people living with HIV with treatment failure and newly diagnosed individuals in all 17 counties and cities in Liangshan Prefecture between 2021 and 2023.ResultsThe majority of study participants were male (66%), farmers (78%) and illiterate (53%). The main HIV-1 transmission routes were heterosexual contact (57%) and injecting drug use (27%). Among the 6,298 successfully obtained pol sequences the following HIV-1 variants were identified: CRF07_BC (93.9%), CRF08_BC (3.3%), CRF01_AE (1.4%), URFs (0.9%), CRF105_0108 (0.1%), CRF55_01B (0.1%), subtype B (0.1%), subtype C (0.1%), CRF88_BC (0.1%), CRF83_cpx (0.1%), CRF85_BC (0.03%), CRF67_01B (0.02%), CRF77_cpx (0.02%), and subtype A (0.02%). During the study period, the proportion of CRF07_BC gradually decreased, while other HIV-1 variants increased, a shift seen across all counties in Liangshan Prefecture. Newly diagnosed patients mainly acquired HIV through heterosexual transmission (86.7%), had a lower proportion of CRF07_BC (90.9%) and higher proportion of other HIV-1 variants, compared to treatment failure patients.ConclusionFuture prevention and control policies need to take these changes into account. |
| format | Article |
| id | doaj-art-376972bb9c164fd794413a28fdc48080 |
| institution | DOAJ |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-376972bb9c164fd794413a28fdc480802025-08-20T03:01:47ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-03-011610.3389/fmicb.2025.15208641520864The changing molecular epidemiology of HIV-1 in Liangshan prefecture, China, in 2021–2023Rong Pei0Rong Pei1Ling Su2Chunnong Jike3Gang Yu4Ju Wang5Lin Xiao6Yubing Wang7Maogang Shen8Chang Zhou9Jiayi Liao10Yulian Zhang11Yifei Zheng12Joris Hemelaar13Nuffield Department of Population Health, Infectious Disease Epidemiology Unit, National Perinatal Epidemiology Unit, University of Oxford, Oxford, United KingdomSchool of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention, Chengdu, ChinaLiangshan Prefecture Centre for Disease Control and Prevention, Xichang, Xichang, ChinaLiangshan Prefecture Centre for Disease Control and Prevention, Xichang, Xichang, ChinaLiangshan Prefecture Centre for Disease Control and Prevention, Xichang, Xichang, ChinaLiangshan Prefecture Centre for Disease Control and Prevention, Xichang, Xichang, ChinaLiangshan Prefecture Centre for Disease Control and Prevention, Xichang, Xichang, ChinaLiangshan Prefecture Centre for Disease Control and Prevention, Xichang, Xichang, ChinaSichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention, Chengdu, ChinaSchool of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaNuffield Department of Population Health, Infectious Disease Epidemiology Unit, National Perinatal Epidemiology Unit, University of Oxford, Oxford, United KingdomIntroductionLiangshan Prefecture is one of the areas in China most severely affected by human immunodeficiency virus (HIV), but little is known about the molecular epidemiology of HIV-1 in this area. We aimed to analyze the distribution of HIV-1 genetic variants in Liangshan Prefecture in recent years.Methods8,523 blood samples were collected from people living with HIV with treatment failure and newly diagnosed individuals in all 17 counties and cities in Liangshan Prefecture between 2021 and 2023.ResultsThe majority of study participants were male (66%), farmers (78%) and illiterate (53%). The main HIV-1 transmission routes were heterosexual contact (57%) and injecting drug use (27%). Among the 6,298 successfully obtained pol sequences the following HIV-1 variants were identified: CRF07_BC (93.9%), CRF08_BC (3.3%), CRF01_AE (1.4%), URFs (0.9%), CRF105_0108 (0.1%), CRF55_01B (0.1%), subtype B (0.1%), subtype C (0.1%), CRF88_BC (0.1%), CRF83_cpx (0.1%), CRF85_BC (0.03%), CRF67_01B (0.02%), CRF77_cpx (0.02%), and subtype A (0.02%). During the study period, the proportion of CRF07_BC gradually decreased, while other HIV-1 variants increased, a shift seen across all counties in Liangshan Prefecture. Newly diagnosed patients mainly acquired HIV through heterosexual transmission (86.7%), had a lower proportion of CRF07_BC (90.9%) and higher proportion of other HIV-1 variants, compared to treatment failure patients.ConclusionFuture prevention and control policies need to take these changes into account.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1520864/fullHIV-1molecular epidemiologycirculating recombinant formssubtypeunique recombinant forms |
| spellingShingle | Rong Pei Rong Pei Ling Su Chunnong Jike Gang Yu Ju Wang Lin Xiao Yubing Wang Maogang Shen Chang Zhou Jiayi Liao Yulian Zhang Yifei Zheng Joris Hemelaar The changing molecular epidemiology of HIV-1 in Liangshan prefecture, China, in 2021–2023 Frontiers in Microbiology HIV-1 molecular epidemiology circulating recombinant forms subtype unique recombinant forms |
| title | The changing molecular epidemiology of HIV-1 in Liangshan prefecture, China, in 2021–2023 |
| title_full | The changing molecular epidemiology of HIV-1 in Liangshan prefecture, China, in 2021–2023 |
| title_fullStr | The changing molecular epidemiology of HIV-1 in Liangshan prefecture, China, in 2021–2023 |
| title_full_unstemmed | The changing molecular epidemiology of HIV-1 in Liangshan prefecture, China, in 2021–2023 |
| title_short | The changing molecular epidemiology of HIV-1 in Liangshan prefecture, China, in 2021–2023 |
| title_sort | changing molecular epidemiology of hiv 1 in liangshan prefecture china in 2021 2023 |
| topic | HIV-1 molecular epidemiology circulating recombinant forms subtype unique recombinant forms |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1520864/full |
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