Substituted-Amidine Functionalized Monocyclic β-Lactams: Synthesis and In Vitro Antibacterial Profile

Substituted-Amidine Functionalized Monocyclic β-Lactams: Synthesis and In Vitro Antibacterial Profile

Background. Owing to the intrinsic stability against common β-lactamases and metallo-lactamases, monobactams gathered special attention in antibiotic drug development. However, so far, aztreonam is the only monobactam approved by FDA for clinical use. We designed new derivatives of aztreonam to enha...

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Main Authors: Lili He, Lijuan Zhai, Jian Sun, Jingwen Ji, Jinbo Ji, Yuanbai Liu, Yangxiu Mu, Yuanyu Gao, Dong Tang, Rui Jiang, Ko Ko Myo, Zaw Min Thu, Haikang Yang, Zafar Iqbal, Zhixiang Yang
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2021/9955206
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http://dx.doi.org/10.1155/2021/9955206

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