Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum?
Abstract Objectives This study aimed to investigate the presence of asprosin hormone in the biological fluids of patients with periodontal inflammation and compare it to those with periodontal healthy. Materials and methods Seventy-five individuals between the ages of 18 to 45, 25 periodontal health...
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2025-04-01
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| Online Access: | https://doi.org/10.1186/s12903-025-06014-1 |
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| author | Sedat Tutuş Abdulsamet Tanık Osman Fatih Arpağ Muhittin Önderci |
| author_facet | Sedat Tutuş Abdulsamet Tanık Osman Fatih Arpağ Muhittin Önderci |
| author_sort | Sedat Tutuş |
| collection | DOAJ |
| description | Abstract Objectives This study aimed to investigate the presence of asprosin hormone in the biological fluids of patients with periodontal inflammation and compare it to those with periodontal healthy. Materials and methods Seventy-five individuals between the ages of 18 to 45, 25 periodontal healthy, 25 with gingivitis, and 25 with periodontitis, were included in the study. Gingival crevicular fluid (GCF), blood serum and saliva were obtained from individuals in each group. Tumour necrosis factor-alpha (TNF-α) and asprosin levels in these fluids were determined using the ELISA. Clinical periodontal measurements were recorded and body mass index was calculated. One-way ANOVA and Bonferroni tests were performed for statistical analysis. Spearman test was used to evaluate correlations. The significance level was determined as p < 0.05. Results Body mass index values were not different between the groups (p = 0.446). Clinical periodontal measurements were significantly higher in the periodontitis group. Concentrations of TNF-α in GCF, serum and saliva increased significantly in patients with gingivitis and periodontitis (p < 0.001). The higher TNF-α levels were obtained in patients with periodontitis than in individuals with gingivitis (p = 0.001). While asprosin levels were found to be significantly higher in patients with gingivitis and periodontitis (p < 0.001), no significant difference was observed between both groups (p > 0.05). GCF-asprosin levels were positively correlated with the concentrations in serum and saliva in all individuals included in the study (p < 0.05). Conclusion The periodontal inflammation caused an increase in asprosin hormone in gingival crevicular fluid independently of the type of periodontal disease. Trial registration This study is registered with number of “NCT06627972” in ClinicalTrials.gov website from the date of October 3, 2024. |
| format | Article |
| id | doaj-art-3767050d663a4f2e8bf1ac09e5da4590 |
| institution | DOAJ |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-3767050d663a4f2e8bf1ac09e5da45902025-08-20T02:55:32ZengBMCBMC Oral Health1472-68312025-04-012511910.1186/s12903-025-06014-1Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum?Sedat Tutuş0Abdulsamet Tanık1Osman Fatih Arpağ2Muhittin Önderci3Kücükcekmece Oral and Dental Health HospitalDepartment of Periodontology, Faculty of Dentistry, Adıyaman UniversityDepartment of Periodontology, Faculty of Dentistry, Hatay Mustafa Kemal UniversityDepartment of Medical Biochemistry, Faculty of Medicine, Adıyaman UniversityAbstract Objectives This study aimed to investigate the presence of asprosin hormone in the biological fluids of patients with periodontal inflammation and compare it to those with periodontal healthy. Materials and methods Seventy-five individuals between the ages of 18 to 45, 25 periodontal healthy, 25 with gingivitis, and 25 with periodontitis, were included in the study. Gingival crevicular fluid (GCF), blood serum and saliva were obtained from individuals in each group. Tumour necrosis factor-alpha (TNF-α) and asprosin levels in these fluids were determined using the ELISA. Clinical periodontal measurements were recorded and body mass index was calculated. One-way ANOVA and Bonferroni tests were performed for statistical analysis. Spearman test was used to evaluate correlations. The significance level was determined as p < 0.05. Results Body mass index values were not different between the groups (p = 0.446). Clinical periodontal measurements were significantly higher in the periodontitis group. Concentrations of TNF-α in GCF, serum and saliva increased significantly in patients with gingivitis and periodontitis (p < 0.001). The higher TNF-α levels were obtained in patients with periodontitis than in individuals with gingivitis (p = 0.001). While asprosin levels were found to be significantly higher in patients with gingivitis and periodontitis (p < 0.001), no significant difference was observed between both groups (p > 0.05). GCF-asprosin levels were positively correlated with the concentrations in serum and saliva in all individuals included in the study (p < 0.05). Conclusion The periodontal inflammation caused an increase in asprosin hormone in gingival crevicular fluid independently of the type of periodontal disease. Trial registration This study is registered with number of “NCT06627972” in ClinicalTrials.gov website from the date of October 3, 2024.https://doi.org/10.1186/s12903-025-06014-1Gingival crevicular fluidAsprosin hormoneTumour necrosis factor alphaGingivitisPeriodontitis |
| spellingShingle | Sedat Tutuş Abdulsamet Tanık Osman Fatih Arpağ Muhittin Önderci Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum? BMC Oral Health Gingival crevicular fluid Asprosin hormone Tumour necrosis factor alpha Gingivitis Periodontitis |
| title | Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum? |
| title_full | Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum? |
| title_fullStr | Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum? |
| title_full_unstemmed | Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum? |
| title_short | Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum? |
| title_sort | is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid saliva and serum |
| topic | Gingival crevicular fluid Asprosin hormone Tumour necrosis factor alpha Gingivitis Periodontitis |
| url | https://doi.org/10.1186/s12903-025-06014-1 |
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