TRANSPLANTATION OF AUTOLOGOUS MESENCHYMAL STEM CELLS IN THE EXPERIMENTAL MYCOBACTERIAL INFECTION: IMPACT OF CONDITIONING
The use of mesenchymal stem cells (MSC) in immune therapy of drug resistant tuberculosis is to be experimentally justified. The impact of non-conditioned and poly(A:U)-conditioned MSC on the course of BCG-infection in mice has been studied. It has been proved that double administration of MSC to mic...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2015-12-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/827 |
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| author | Ya. Sh. Shvarts S. N. Belogorodtsev P. N. Filimonov A. G. Cherednichenko |
| author_facet | Ya. Sh. Shvarts S. N. Belogorodtsev P. N. Filimonov A. G. Cherednichenko |
| author_sort | Ya. Sh. Shvarts |
| collection | DOAJ |
| description | The use of mesenchymal stem cells (MSC) in immune therapy of drug resistant tuberculosis is to be experimentally justified. The impact of non-conditioned and poly(A:U)-conditioned MSC on the course of BCG-infection in mice has been studied. It has been proved that double administration of MSC to mice of BALB/c line in 11 and 12.5 weeks after infection with BCG caused significant reduction of granulomas formation and activated the mycobacterial growth. On the contrary the similar administration of MSC with poly(A:U) conditioning significantly inhibited the mycobacterial growth and provided no effect on granulomas formation. Non-conditioned MSC manifested immune suppression properties, and poly(A:U) conditioning caused their pro-inflammatory polarization in vitro. It has been concluded that MSC therapy of mycobacterial infection can be effective in case of targeted formation of pro-inflammatory immune-phenotype of MSC. |
| format | Article |
| id | doaj-art-37618cded24f42e9bd2fdf06a4242e30 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2015-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-37618cded24f42e9bd2fdf06a4242e302025-08-20T01:47:51ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062015-12-010123136827TRANSPLANTATION OF AUTOLOGOUS MESENCHYMAL STEM CELLS IN THE EXPERIMENTAL MYCOBACTERIAL INFECTION: IMPACT OF CONDITIONINGYa. Sh. Shvarts0S. N. Belogorodtsev1P. N. Filimonov2A. G. Cherednichenko3Research Institute of Therapy and Preventive MedicineResearch Institute of Fundamental and Clinical ImmunologyNovosibirsk Tuberculosis Research InstituteNovosibirsk Tuberculosis Research InstituteThe use of mesenchymal stem cells (MSC) in immune therapy of drug resistant tuberculosis is to be experimentally justified. The impact of non-conditioned and poly(A:U)-conditioned MSC on the course of BCG-infection in mice has been studied. It has been proved that double administration of MSC to mice of BALB/c line in 11 and 12.5 weeks after infection with BCG caused significant reduction of granulomas formation and activated the mycobacterial growth. On the contrary the similar administration of MSC with poly(A:U) conditioning significantly inhibited the mycobacterial growth and provided no effect on granulomas formation. Non-conditioned MSC manifested immune suppression properties, and poly(A:U) conditioning caused their pro-inflammatory polarization in vitro. It has been concluded that MSC therapy of mycobacterial infection can be effective in case of targeted formation of pro-inflammatory immune-phenotype of MSC.https://www.tibl-journal.com/jour/article/view/827bcg-granulomatosistuberculosismesenchymal stem cellscellular therapy |
| spellingShingle | Ya. Sh. Shvarts S. N. Belogorodtsev P. N. Filimonov A. G. Cherednichenko TRANSPLANTATION OF AUTOLOGOUS MESENCHYMAL STEM CELLS IN THE EXPERIMENTAL MYCOBACTERIAL INFECTION: IMPACT OF CONDITIONING Туберкулез и болезни лёгких bcg-granulomatosis tuberculosis mesenchymal stem cells cellular therapy |
| title | TRANSPLANTATION OF AUTOLOGOUS MESENCHYMAL STEM CELLS IN THE EXPERIMENTAL MYCOBACTERIAL INFECTION: IMPACT OF CONDITIONING |
| title_full | TRANSPLANTATION OF AUTOLOGOUS MESENCHYMAL STEM CELLS IN THE EXPERIMENTAL MYCOBACTERIAL INFECTION: IMPACT OF CONDITIONING |
| title_fullStr | TRANSPLANTATION OF AUTOLOGOUS MESENCHYMAL STEM CELLS IN THE EXPERIMENTAL MYCOBACTERIAL INFECTION: IMPACT OF CONDITIONING |
| title_full_unstemmed | TRANSPLANTATION OF AUTOLOGOUS MESENCHYMAL STEM CELLS IN THE EXPERIMENTAL MYCOBACTERIAL INFECTION: IMPACT OF CONDITIONING |
| title_short | TRANSPLANTATION OF AUTOLOGOUS MESENCHYMAL STEM CELLS IN THE EXPERIMENTAL MYCOBACTERIAL INFECTION: IMPACT OF CONDITIONING |
| title_sort | transplantation of autologous mesenchymal stem cells in the experimental mycobacterial infection impact of conditioning |
| topic | bcg-granulomatosis tuberculosis mesenchymal stem cells cellular therapy |
| url | https://www.tibl-journal.com/jour/article/view/827 |
| work_keys_str_mv | AT yashshvarts transplantationofautologousmesenchymalstemcellsintheexperimentalmycobacterialinfectionimpactofconditioning AT snbelogorodtsev transplantationofautologousmesenchymalstemcellsintheexperimentalmycobacterialinfectionimpactofconditioning AT pnfilimonov transplantationofautologousmesenchymalstemcellsintheexperimentalmycobacterialinfectionimpactofconditioning AT agcherednichenko transplantationofautologousmesenchymalstemcellsintheexperimentalmycobacterialinfectionimpactofconditioning |