The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus
Objectives. To explore the difference of glucose fluctuations between the normal subjects and diabetes mellitus (DM) patients and explore their impact on the development of CAD in type 2 DM patients. Methods. The subjects were divided into 3 groups: normal control (group A, ), type 2 DM patients wit...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/576916 |
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| author | Xingguang Zhang Xiuping Xu Xiumin Jiao Jinxiao Wu Shujing Zhou Xiaofeng Lv |
| author_facet | Xingguang Zhang Xiuping Xu Xiumin Jiao Jinxiao Wu Shujing Zhou Xiaofeng Lv |
| author_sort | Xingguang Zhang |
| collection | DOAJ |
| description | Objectives. To explore the difference of glucose fluctuations between the normal subjects and diabetes mellitus (DM) patients and explore their impact on the development of CAD in type 2 DM patients. Methods. The subjects were divided into 3 groups: normal control (group A, ), type 2 DM patients without cardiovascular complications (group B, ), and type 2 DM patients with cardiovascular complications (group C, ). The SYNTAX scores were collected in group C. CGMS for 72 h was applied on all the subjects. The indexes such as MBG and the LAGE were calculated. Glycemic excursions were compared between groups A, B, and C, respectively. Results. The tested indexes had significant differences among the three groups. SYNTAX scores are related to systolic blood pressure, CRP, MAGE, and HbA1c and are significantly correlated at 6:00–8:00 and 11:00–13:00 time points in group C. Conclusions. Compared with normal subjects, T2DM patients have greater blood glucose fluctuations; T2DM patients with CAD have larger glucose fluctuations than T2DM patients without CAD. Blood glucose fluctuations are positively correlated with carotid artery intima-media thickness in T2DM patients and have a significant influence on the development of coronary artery. |
| format | Article |
| id | doaj-art-3760b166ba28443687a7fe1271a4ade0 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3760b166ba28443687a7fe1271a4ade02025-02-03T05:46:44ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/576916576916The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes MellitusXingguang Zhang0Xiuping Xu1Xiumin Jiao2Jinxiao Wu3Shujing Zhou4Xiaofeng Lv5General Hospital of Beijing Military Region, No. 5 Nan Men Cang, Dongcheng Distrct, Beijing 100700, ChinaGeneral Hospital of Beijing Military Region, No. 5 Nan Men Cang, Dongcheng Distrct, Beijing 100700, ChinaGeneral Hospital of Beijing Military Region, No. 5 Nan Men Cang, Dongcheng Distrct, Beijing 100700, ChinaGeneral Hospital of Beijing Military Region, No. 5 Nan Men Cang, Dongcheng Distrct, Beijing 100700, ChinaGeneral Hospital of Beijing Military Region, No. 5 Nan Men Cang, Dongcheng Distrct, Beijing 100700, ChinaGeneral Hospital of Beijing Military Region, No. 5 Nan Men Cang, Dongcheng Distrct, Beijing 100700, ChinaObjectives. To explore the difference of glucose fluctuations between the normal subjects and diabetes mellitus (DM) patients and explore their impact on the development of CAD in type 2 DM patients. Methods. The subjects were divided into 3 groups: normal control (group A, ), type 2 DM patients without cardiovascular complications (group B, ), and type 2 DM patients with cardiovascular complications (group C, ). The SYNTAX scores were collected in group C. CGMS for 72 h was applied on all the subjects. The indexes such as MBG and the LAGE were calculated. Glycemic excursions were compared between groups A, B, and C, respectively. Results. The tested indexes had significant differences among the three groups. SYNTAX scores are related to systolic blood pressure, CRP, MAGE, and HbA1c and are significantly correlated at 6:00–8:00 and 11:00–13:00 time points in group C. Conclusions. Compared with normal subjects, T2DM patients have greater blood glucose fluctuations; T2DM patients with CAD have larger glucose fluctuations than T2DM patients without CAD. Blood glucose fluctuations are positively correlated with carotid artery intima-media thickness in T2DM patients and have a significant influence on the development of coronary artery.http://dx.doi.org/10.1155/2013/576916 |
| spellingShingle | Xingguang Zhang Xiuping Xu Xiumin Jiao Jinxiao Wu Shujing Zhou Xiaofeng Lv The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus Journal of Diabetes Research |
| title | The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_full | The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_fullStr | The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_full_unstemmed | The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_short | The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_sort | effects of glucose fluctuation on the severity of coronary artery disease in type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2013/576916 |
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