Research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence
Neurogenic fecal incontinence refers to the dysfunction of anal sphincter contraction caused by degenerative atrophy of the anal sphincter secondary to pudendal nerve injury, manifested as involuntary leakage of feces from the anus. Muscle satellite cells are a group of adult stem cells in skeletal...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Colorectal & Anal Surgery
2024-08-01
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| Series: | 结直肠肛门外科 |
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| Online Access: | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=316&cateName=2024%E5%B9%B4%20%E7%AC%AC30%E5%8D%B7%20%E7%AC%AC4%E6%9C%9F |
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| author | He Jinchao Wang Qunbo Qin Qin Zhao Ling Dong Qingjun |
| author_facet | He Jinchao Wang Qunbo Qin Qin Zhao Ling Dong Qingjun |
| author_sort | He Jinchao |
| collection | DOAJ |
| description | Neurogenic fecal incontinence refers to the dysfunction of anal sphincter contraction caused by degenerative atrophy of the anal sphincter secondary to pudendal nerve injury, manifested as involuntary leakage of feces from the anus. Muscle satellite cells are a group of adult stem cells in skeletal muscle that can be activated and differentiate into stem cells and myoblasts after skeletal muscle injury, reconstructing muscle fibers. The process of atrophy of the external anal sphincter is intimately linked to the number and activation-differentiation level of muscle satellite cells, and the activation and proliferation of muscle satellite cells play a pivotal role in the injury and regeneration of the anal sphincter. This process is regulated by the ecological niche and signal transduction of various cells and cytokines, serving as an important target for the treatment of neurogenic fecal incontinence. This article reviews the research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence. |
| format | Article |
| id | doaj-art-375caaa818d940d2a84dadde17b3ab0a |
| institution | DOAJ |
| issn | 1674-0491 |
| language | zho |
| publishDate | 2024-08-01 |
| publisher | Editorial Office of Journal of Colorectal & Anal Surgery |
| record_format | Article |
| series | 结直肠肛门外科 |
| spelling | doaj-art-375caaa818d940d2a84dadde17b3ab0a2025-08-20T03:10:05ZzhoEditorial Office of Journal of Colorectal & Anal Surgery结直肠肛门外科1674-04912024-08-0130451051410.19668/j.cnki.issn1674-0491.2024.04.022Research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinenceHe Jinchao0Wang Qunbo1Qin Qin2Zhao Ling3Dong Qingjun4Department of Colorectal Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaDepartment of Colorectal Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaDepartment of Colorectal Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaSchool of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaDepartment of Colorectal Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaNeurogenic fecal incontinence refers to the dysfunction of anal sphincter contraction caused by degenerative atrophy of the anal sphincter secondary to pudendal nerve injury, manifested as involuntary leakage of feces from the anus. Muscle satellite cells are a group of adult stem cells in skeletal muscle that can be activated and differentiate into stem cells and myoblasts after skeletal muscle injury, reconstructing muscle fibers. The process of atrophy of the external anal sphincter is intimately linked to the number and activation-differentiation level of muscle satellite cells, and the activation and proliferation of muscle satellite cells play a pivotal role in the injury and regeneration of the anal sphincter. This process is regulated by the ecological niche and signal transduction of various cells and cytokines, serving as an important target for the treatment of neurogenic fecal incontinence. This article reviews the research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence.https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=316&cateName=2024%E5%B9%B4%20%E7%AC%AC30%E5%8D%B7%20%E7%AC%AC4%E6%9C%9Fneurogenic fecal incontinencemuscle satellite cellsdegenerative atrophysphincter regeneration |
| spellingShingle | He Jinchao Wang Qunbo Qin Qin Zhao Ling Dong Qingjun Research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence 结直肠肛门外科 neurogenic fecal incontinence muscle satellite cells degenerative atrophy sphincter regeneration |
| title | Research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence |
| title_full | Research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence |
| title_fullStr | Research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence |
| title_full_unstemmed | Research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence |
| title_short | Research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence |
| title_sort | research progress on the effect of muscle satellite cells on anal sphincter repair in neurogenic fecal incontinence |
| topic | neurogenic fecal incontinence muscle satellite cells degenerative atrophy sphincter regeneration |
| url | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=316&cateName=2024%E5%B9%B4%20%E7%AC%AC30%E5%8D%B7%20%E7%AC%AC4%E6%9C%9F |
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