Imputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV Diagnosis
Objectives. Since subjects may have been diagnosed before cohort entry, analysis of late HIV diagnosis (LD) is usually restricted to the newly diagnosed. We estimate the magnitude and risk factors of LD in a cohort of seroprevalent individuals by imputing seroconversion dates. Methods. Multicenter...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2012/725412 |
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| author | Paz Sobrino-Vegas Santiago Pérez-Hoyos Ronald Geskus Belén Padilla Ferrán Segura Rafael Rubio Jorge del Romero Jesus Santos Santiago Moreno Julia del Amo |
| author_facet | Paz Sobrino-Vegas Santiago Pérez-Hoyos Ronald Geskus Belén Padilla Ferrán Segura Rafael Rubio Jorge del Romero Jesus Santos Santiago Moreno Julia del Amo |
| author_sort | Paz Sobrino-Vegas |
| collection | DOAJ |
| description | Objectives. Since subjects may have been diagnosed before cohort entry, analysis of late HIV diagnosis (LD) is usually restricted to the newly diagnosed. We estimate the magnitude and risk factors of LD in a cohort of seroprevalent individuals by imputing seroconversion dates. Methods. Multicenter cohort of HIV-positive subjects who were treatment naive at entry, in Spain, 2004–2008. Multiple-imputation techniques were used. Subjects with times to HIV diagnosis longer than 4.19 years were considered LD. Results. Median time to HIV diagnosis was 2.8 years in the whole cohort of 3,667 subjects. Factors significantly associated with LD were: male sex; Sub-Saharan African, Latin-American origin compared to Spaniards; and older age. In 2,928 newly diagnosed subjects, median time to diagnosis was 3.3 years, and LD was more common in injecting drug users. Conclusions. Estimates of the magnitude and risk factors of LD for the whole cohort differ from those obtained for new HIV diagnoses. |
| format | Article |
| id | doaj-art-375007948ebb46468b7e21fcfb1089b0 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-375007948ebb46468b7e21fcfb1089b02025-08-20T03:55:01ZengWileyAIDS Research and Treatment2090-12402090-12592012-01-01201210.1155/2012/725412725412Imputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV DiagnosisPaz Sobrino-Vegas0Santiago Pérez-Hoyos1Ronald Geskus2Belén Padilla3Ferrán Segura4Rafael Rubio5Jorge del Romero6Jesus Santos7Santiago Moreno8Julia del Amo9Red de Investigación en Sida, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, 28029 Madrid, SpainInstitut de Recerca Hospital Vall Hebrón, Unitat Suport Metodològic a l’Investigació Biomedica, 08035 Barcelona, SpainCluster of Infectious Diseases, Amsterdam Public Health Service, Amsterdam, The NetherlandsUnidad de Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainCorporació Sanitària Parc Taulí, 08208 Sabadell, SpainUnidad de VIH, Hospital Universitario Doce de Octubre, 28041 Madrid, SpainCentro Sanitario Sandoval, 28010 Madrid, SpainHospital Virgen de la Victoria, 29010 Málaga, SpainServicio de Enfermedades Infecciosas, Hospital Universitario Ramón y Cajal, 28034 Madrid, SpainRed de Investigación en Sida, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, 28029 Madrid, SpainObjectives. Since subjects may have been diagnosed before cohort entry, analysis of late HIV diagnosis (LD) is usually restricted to the newly diagnosed. We estimate the magnitude and risk factors of LD in a cohort of seroprevalent individuals by imputing seroconversion dates. Methods. Multicenter cohort of HIV-positive subjects who were treatment naive at entry, in Spain, 2004–2008. Multiple-imputation techniques were used. Subjects with times to HIV diagnosis longer than 4.19 years were considered LD. Results. Median time to HIV diagnosis was 2.8 years in the whole cohort of 3,667 subjects. Factors significantly associated with LD were: male sex; Sub-Saharan African, Latin-American origin compared to Spaniards; and older age. In 2,928 newly diagnosed subjects, median time to diagnosis was 3.3 years, and LD was more common in injecting drug users. Conclusions. Estimates of the magnitude and risk factors of LD for the whole cohort differ from those obtained for new HIV diagnoses.http://dx.doi.org/10.1155/2012/725412 |
| spellingShingle | Paz Sobrino-Vegas Santiago Pérez-Hoyos Ronald Geskus Belén Padilla Ferrán Segura Rafael Rubio Jorge del Romero Jesus Santos Santiago Moreno Julia del Amo Imputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV Diagnosis AIDS Research and Treatment |
| title | Imputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV Diagnosis |
| title_full | Imputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV Diagnosis |
| title_fullStr | Imputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV Diagnosis |
| title_full_unstemmed | Imputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV Diagnosis |
| title_short | Imputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV Diagnosis |
| title_sort | imputation of the date of hiv seroconversion in a cohort of seroprevalent subjects implications for analysis of late hiv diagnosis |
| url | http://dx.doi.org/10.1155/2012/725412 |
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