Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease
Background. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase. A previous rat study revealed an ADMA lowering effect following treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs). We sought to examine if an association between plasma ADMA and risk of a...
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/201742 |
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| author | Heidi Borgeraas Elin Strand Eva Ringdal Pedersen Jutta Dierkes Per Magne Ueland Reinhard Seifert Eirik Rebnord Wilberg Pavol Bohov Rolf K. Berge Dennis W. T. Nilsen Ottar Nygård |
| author_facet | Heidi Borgeraas Elin Strand Eva Ringdal Pedersen Jutta Dierkes Per Magne Ueland Reinhard Seifert Eirik Rebnord Wilberg Pavol Bohov Rolf K. Berge Dennis W. T. Nilsen Ottar Nygård |
| author_sort | Heidi Borgeraas |
| collection | DOAJ |
| description | Background. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase. A previous rat study revealed an ADMA lowering effect following treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs). We sought to examine if an association between plasma ADMA and risk of acute myocardial infarction (AMI) was modified by serum n-3 PUFA status. Methods. The cohort included 1364 patients who underwent coronary angiography for suspected coronary artery disease in 2000-2001. Fatal and nonfatal AMI events were registered until December 31, 2006. Risk associations with AMI were estimated across ADMA quartiles (linear trend) and the upper decile. Results. No association between concentration of any n-3 PUFA and ADMA was observed. Only ADMA levels in upper decile were significantly associated with AMI with a multivariate adjusted hazard ratio (HR) (95% confidence interval) versus the rest of the population of 2.11 (1.34, 3.32). The association was strengthened among patients with below median levels of α-linolenic acid (ALA) (HR 3.12 (1.64, 5.93)), but was only influenced by longer chain n-3 PUFA after additional adjustments for HbA1c, estimated glomerular filtration rate, and hypercholesterolemia. Conclusions. The association of ADMA with risk of AMI is influenced by serum n-3 PUFA and particularly ALA. |
| format | Article |
| id | doaj-art-374c5d871bcc4aa19edffa37ea02d042 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-374c5d871bcc4aa19edffa37ea02d0422025-02-03T01:31:34ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/201742201742Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery DiseaseHeidi Borgeraas0Elin Strand1Eva Ringdal Pedersen2Jutta Dierkes3Per Magne Ueland4Reinhard Seifert5Eirik Rebnord Wilberg6Pavol Bohov7Rolf K. Berge8Dennis W. T. Nilsen9Ottar Nygård10Institute of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, 5021 Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayInstitute of Medicine, Haukeland University Hospital, 5021 Bergen, NorwayBackground. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase. A previous rat study revealed an ADMA lowering effect following treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs). We sought to examine if an association between plasma ADMA and risk of acute myocardial infarction (AMI) was modified by serum n-3 PUFA status. Methods. The cohort included 1364 patients who underwent coronary angiography for suspected coronary artery disease in 2000-2001. Fatal and nonfatal AMI events were registered until December 31, 2006. Risk associations with AMI were estimated across ADMA quartiles (linear trend) and the upper decile. Results. No association between concentration of any n-3 PUFA and ADMA was observed. Only ADMA levels in upper decile were significantly associated with AMI with a multivariate adjusted hazard ratio (HR) (95% confidence interval) versus the rest of the population of 2.11 (1.34, 3.32). The association was strengthened among patients with below median levels of α-linolenic acid (ALA) (HR 3.12 (1.64, 5.93)), but was only influenced by longer chain n-3 PUFA after additional adjustments for HbA1c, estimated glomerular filtration rate, and hypercholesterolemia. Conclusions. The association of ADMA with risk of AMI is influenced by serum n-3 PUFA and particularly ALA.http://dx.doi.org/10.1155/2012/201742 |
| spellingShingle | Heidi Borgeraas Elin Strand Eva Ringdal Pedersen Jutta Dierkes Per Magne Ueland Reinhard Seifert Eirik Rebnord Wilberg Pavol Bohov Rolf K. Berge Dennis W. T. Nilsen Ottar Nygård Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease Cardiology Research and Practice |
| title | Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease |
| title_full | Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease |
| title_fullStr | Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease |
| title_full_unstemmed | Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease |
| title_short | Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease |
| title_sort | omega 3 status and the relationship between plasma asymmetric dimethylarginine and risk of myocardial infarction in patients with suspected coronary artery disease |
| url | http://dx.doi.org/10.1155/2012/201742 |
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