Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study
PurposeThe estimated glucose disposal rate (eGDR) serves as a straightforward and noninvasive indicator of insulin resistance (IR). This study aims to explore the association between eGDR and the risk of abdominal aortic calcification (AAC).MethodsWe utilized data from adult participants (≥40 years...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1560577/full |
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| author | Bo Zhao Zongliang Yu Fengyan Tang Zhenqin Feng Junfeng Wang Zhaoxiang Wang |
| author_facet | Bo Zhao Zongliang Yu Fengyan Tang Zhenqin Feng Junfeng Wang Zhaoxiang Wang |
| author_sort | Bo Zhao |
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| description | PurposeThe estimated glucose disposal rate (eGDR) serves as a straightforward and noninvasive indicator of insulin resistance (IR). This study aims to explore the association between eGDR and the risk of abdominal aortic calcification (AAC).MethodsWe utilized data from adult participants (≥40 years old, n=3006) from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) database. AAC was measured by dual-energy X-ray absorptiometry and quantified using the Kauppila score. Severe AAC (SAAC) was defined as an AAC score > 6. Logistic regression, restricted cubic spline (RCS), and subgroup analysis were used to analyze the relationship between eGDR and SAAC risk.ResultsIn fully adjusted models, eGDR was found to be negatively associated with SAAC (OR=0.86, 95%CI:0.79–0.94, P<0.001). Compared to participants in the lowest eGDR quantile, those in the highest quantile exhibited a lower risk of SAAC (OR=0.47, 95%CI:0.25–0.91, P=0.026). The RCS analysis indicates a nonlinear relationship between eGDR and SAAC risk, with a turning point at 7.05 mg/kg/min. Subgroup analysis showed that the association between eGDR and SAAC risk was more significant in women.ConclusionsThe degree of IR assessed by eGDR is associated with SAAC risk. The eGDR shows promise as an epidemiological tool for evaluating the influence of IR on AAC. |
| format | Article |
| id | doaj-art-374504607ba2439dae4e134b6a8e2a92 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-374504607ba2439dae4e134b6a8e2a922025-08-20T03:53:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.15605771560577Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort studyBo Zhao0Zongliang Yu1Fengyan Tang2Zhenqin Feng3Junfeng Wang4Zhaoxiang Wang5Department of Cardiology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, ChinaDepartment of Cardiology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, ChinaDepartment of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, ChinaDepartment of Cardiology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, ChinaDepartment of Cardiology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, ChinaDepartment of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, ChinaPurposeThe estimated glucose disposal rate (eGDR) serves as a straightforward and noninvasive indicator of insulin resistance (IR). This study aims to explore the association between eGDR and the risk of abdominal aortic calcification (AAC).MethodsWe utilized data from adult participants (≥40 years old, n=3006) from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) database. AAC was measured by dual-energy X-ray absorptiometry and quantified using the Kauppila score. Severe AAC (SAAC) was defined as an AAC score > 6. Logistic regression, restricted cubic spline (RCS), and subgroup analysis were used to analyze the relationship between eGDR and SAAC risk.ResultsIn fully adjusted models, eGDR was found to be negatively associated with SAAC (OR=0.86, 95%CI:0.79–0.94, P<0.001). Compared to participants in the lowest eGDR quantile, those in the highest quantile exhibited a lower risk of SAAC (OR=0.47, 95%CI:0.25–0.91, P=0.026). The RCS analysis indicates a nonlinear relationship between eGDR and SAAC risk, with a turning point at 7.05 mg/kg/min. Subgroup analysis showed that the association between eGDR and SAAC risk was more significant in women.ConclusionsThe degree of IR assessed by eGDR is associated with SAAC risk. The eGDR shows promise as an epidemiological tool for evaluating the influence of IR on AAC.https://www.frontiersin.org/articles/10.3389/fendo.2025.1560577/fullABDOMINAL AORTIC CALCIFICATIONinsulin resistanceestimated glucose disposal rateNHANEScross-sectional study |
| spellingShingle | Bo Zhao Zongliang Yu Fengyan Tang Zhenqin Feng Junfeng Wang Zhaoxiang Wang Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study Frontiers in Endocrinology ABDOMINAL AORTIC CALCIFICATION insulin resistance estimated glucose disposal rate NHANES cross-sectional study |
| title | Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study |
| title_full | Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study |
| title_fullStr | Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study |
| title_full_unstemmed | Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study |
| title_short | Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study |
| title_sort | insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification findings from a nationwide cohort study |
| topic | ABDOMINAL AORTIC CALCIFICATION insulin resistance estimated glucose disposal rate NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1560577/full |
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