Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysis
Abstract INTRODUCTION Blood‐based biomarkers seem promising for the diagnosis of Alzheimer's disease (AD). METHODS We performed a systematic review and meta‐analysis on the potential of blood phosphorylated Tau181 (p‐tau181) to differentiate amyloid‐positive (A+) and amyloid‐negative (A−) subje...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.70068 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850064161063567360 |
|---|---|
| author | Annibale Antonioni Emanuela Maria Raho Lamberto Manzoli Giacomo Koch Maria Elena Flacco Francesco Di Lorenzo |
| author_facet | Annibale Antonioni Emanuela Maria Raho Lamberto Manzoli Giacomo Koch Maria Elena Flacco Francesco Di Lorenzo |
| author_sort | Annibale Antonioni |
| collection | DOAJ |
| description | Abstract INTRODUCTION Blood‐based biomarkers seem promising for the diagnosis of Alzheimer's disease (AD). METHODS We performed a systematic review and meta‐analysis on the potential of blood phosphorylated Tau181 (p‐tau181) to differentiate amyloid‐positive (A+) and amyloid‐negative (A−) subjects. Two meta‐analyses were conducted, showing the mean p‐tau values in blood and cerebrospinal fluid (CSF) in the A+ and A− group, and the second comparing the mean p‐tau concentrations in blood and CSF among A+ versus A‐ participants, by laboratory assessment method. RESULTS Eighteen studies (2764 A+ and 5646 A− subjects) were included. The single‐group meta‐analysis showed mean higher blood p‐tau181 values in the A+ than in the A− group. In the head‐to‐head meta‐analysis, blood p‐tau reliably differentiated A+ patients from A− participants. DISCUSSION Regardless of the laboratory technique, blood p‐tau181 reliably differentiates A+ and A− subjects. Therefore, it might have important applications for early diagnosis and inclusion in clinical trials for AD patients. Highlights The role of blood‐based biomarkers in discriminating AD patients is still uncertain. Blood p‐tau181 distinguishes among amyloid‐positive and amyloid‐negative subjects. Blood p‐tau181 might allow early diagnosis and inclusion in clinical trials. |
| format | Article |
| id | doaj-art-373fac85c7414089bb719fb899373307 |
| institution | DOAJ |
| issn | 2352-8729 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-373fac85c7414089bb719fb8993733072025-08-20T02:49:22ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292025-01-01171n/an/a10.1002/dad2.70068Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysisAnnibale Antonioni0Emanuela Maria Raho1Lamberto Manzoli2Giacomo Koch3Maria Elena Flacco4Francesco Di Lorenzo5Doctoral Program in Translational Neurosciences and Neurotechnologies Department of Neuroscience and Rehabilitation University of Ferrara Ferrara ItalyDepartment of Neuroscience and Rehabilitation University of Ferrara Ferrara ItalyDepartment of Medical and Surgical Sciences University of Bologna Bologna ItalyNon Invasive Brain Stimulation Unit Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Rome ItalyDepartment of Environmental and Prevention Sciences University of Ferrara Ferrara ItalyNon Invasive Brain Stimulation Unit Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Rome ItalyAbstract INTRODUCTION Blood‐based biomarkers seem promising for the diagnosis of Alzheimer's disease (AD). METHODS We performed a systematic review and meta‐analysis on the potential of blood phosphorylated Tau181 (p‐tau181) to differentiate amyloid‐positive (A+) and amyloid‐negative (A−) subjects. Two meta‐analyses were conducted, showing the mean p‐tau values in blood and cerebrospinal fluid (CSF) in the A+ and A− group, and the second comparing the mean p‐tau concentrations in blood and CSF among A+ versus A‐ participants, by laboratory assessment method. RESULTS Eighteen studies (2764 A+ and 5646 A− subjects) were included. The single‐group meta‐analysis showed mean higher blood p‐tau181 values in the A+ than in the A− group. In the head‐to‐head meta‐analysis, blood p‐tau reliably differentiated A+ patients from A− participants. DISCUSSION Regardless of the laboratory technique, blood p‐tau181 reliably differentiates A+ and A− subjects. Therefore, it might have important applications for early diagnosis and inclusion in clinical trials for AD patients. Highlights The role of blood‐based biomarkers in discriminating AD patients is still uncertain. Blood p‐tau181 distinguishes among amyloid‐positive and amyloid‐negative subjects. Blood p‐tau181 might allow early diagnosis and inclusion in clinical trials.https://doi.org/10.1002/dad2.70068Alzheimer's disease (AD)biomarkersbloodCSFmeta‐analysisphosphorylated Tau181 (p‐tau181) |
| spellingShingle | Annibale Antonioni Emanuela Maria Raho Lamberto Manzoli Giacomo Koch Maria Elena Flacco Francesco Di Lorenzo Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysis Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease (AD) biomarkers blood CSF meta‐analysis phosphorylated Tau181 (p‐tau181) |
| title | Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysis |
| title_full | Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysis |
| title_fullStr | Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysis |
| title_full_unstemmed | Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysis |
| title_short | Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysis |
| title_sort | blood phosphorylated tau181 reliably differentiates amyloid positive from amyloid negative subjects in the alzheimer s disease continuum a systematic review and meta analysis |
| topic | Alzheimer's disease (AD) biomarkers blood CSF meta‐analysis phosphorylated Tau181 (p‐tau181) |
| url | https://doi.org/10.1002/dad2.70068 |
| work_keys_str_mv | AT annibaleantonioni bloodphosphorylatedtau181reliablydifferentiatesamyloidpositivefromamyloidnegativesubjectsinthealzheimersdiseasecontinuumasystematicreviewandmetaanalysis AT emanuelamariaraho bloodphosphorylatedtau181reliablydifferentiatesamyloidpositivefromamyloidnegativesubjectsinthealzheimersdiseasecontinuumasystematicreviewandmetaanalysis AT lambertomanzoli bloodphosphorylatedtau181reliablydifferentiatesamyloidpositivefromamyloidnegativesubjectsinthealzheimersdiseasecontinuumasystematicreviewandmetaanalysis AT giacomokoch bloodphosphorylatedtau181reliablydifferentiatesamyloidpositivefromamyloidnegativesubjectsinthealzheimersdiseasecontinuumasystematicreviewandmetaanalysis AT mariaelenaflacco bloodphosphorylatedtau181reliablydifferentiatesamyloidpositivefromamyloidnegativesubjectsinthealzheimersdiseasecontinuumasystematicreviewandmetaanalysis AT francescodilorenzo bloodphosphorylatedtau181reliablydifferentiatesamyloidpositivefromamyloidnegativesubjectsinthealzheimersdiseasecontinuumasystematicreviewandmetaanalysis |