Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes
Abstract Intestine-exclusive metabolic processes involve the degradation of dietary components and xenobiotics through intricate and dynamic interactions between the host epithelial cells and gut microbiota. Disruptions in this fragile equilibrium lead to metabolic and gastrointestinal diseases, hig...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Metabolic Health and Disease |
| Online Access: | https://doi.org/10.1038/s44324-025-00066-1 |
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| author | Jyoti Priyankar Dey |
| author_facet | Jyoti Priyankar Dey |
| author_sort | Jyoti |
| collection | DOAJ |
| description | Abstract Intestine-exclusive metabolic processes involve the degradation of dietary components and xenobiotics through intricate and dynamic interactions between the host epithelial cells and gut microbiota. Disruptions in this fragile equilibrium lead to metabolic and gastrointestinal diseases, highlighting the profound impact of the gut microbiota on the host intestinal metabolic processes. Gut microbes play a crucial role in influencing intestinal metabolic homeostasis by affecting nutrient sensing, gut hormones, neurotransmitters, and redox balance, collectively modulating mucosal gene expression and metabolic signaling pathways. These intestinal-level host-microbe metabolic interactions profoundly impact extra-intestinal tissues and organs. This comprehensive review provides mechanistic insights on the crucial role of gut microbiota in sustaining metabolic health by narrowing down to the gut-level metabolic interactions. |
| format | Article |
| id | doaj-art-373f107bc0cf4edb83e46eb597762fde |
| institution | OA Journals |
| issn | 2948-2828 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Metabolic Health and Disease |
| spelling | doaj-art-373f107bc0cf4edb83e46eb597762fde2025-08-20T02:06:23ZengNature Portfolionpj Metabolic Health and Disease2948-28282025-06-013111910.1038/s44324-025-00066-1Mechanisms and implications of the gut microbial modulation of intestinal metabolic processesJyoti0Priyankar Dey1Department of Biotechnology, Thapar Institute of Engineering and TechnologyDepartment of Biotechnology, Thapar Institute of Engineering and TechnologyAbstract Intestine-exclusive metabolic processes involve the degradation of dietary components and xenobiotics through intricate and dynamic interactions between the host epithelial cells and gut microbiota. Disruptions in this fragile equilibrium lead to metabolic and gastrointestinal diseases, highlighting the profound impact of the gut microbiota on the host intestinal metabolic processes. Gut microbes play a crucial role in influencing intestinal metabolic homeostasis by affecting nutrient sensing, gut hormones, neurotransmitters, and redox balance, collectively modulating mucosal gene expression and metabolic signaling pathways. These intestinal-level host-microbe metabolic interactions profoundly impact extra-intestinal tissues and organs. This comprehensive review provides mechanistic insights on the crucial role of gut microbiota in sustaining metabolic health by narrowing down to the gut-level metabolic interactions.https://doi.org/10.1038/s44324-025-00066-1 |
| spellingShingle | Jyoti Priyankar Dey Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes npj Metabolic Health and Disease |
| title | Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes |
| title_full | Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes |
| title_fullStr | Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes |
| title_full_unstemmed | Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes |
| title_short | Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes |
| title_sort | mechanisms and implications of the gut microbial modulation of intestinal metabolic processes |
| url | https://doi.org/10.1038/s44324-025-00066-1 |
| work_keys_str_mv | AT jyoti mechanismsandimplicationsofthegutmicrobialmodulationofintestinalmetabolicprocesses AT priyankardey mechanismsandimplicationsofthegutmicrobialmodulationofintestinalmetabolicprocesses |