A one-week reduced-carbohydrate diet to mitigate iatrogenic peripheral hyperinsulinemia does not improve insulin sensitivity or endothelial function in a randomized, crossover trial in patients with type 1 diabetes

A one-week reduced-carbohydrate diet to mitigate iatrogenic peripheral hyperinsulinemia does not improve insulin sensitivity or endothelial function in a randomized, crossover trial in patients with type 1 diabetes

Abstract Background Iatrogenic peripheral hyperinsulinemia, resulting from peripheral insulin administration in type 1 diabetes, may increase insulin resistance and impair endothelial function. We hypothesized that lowering iatrogenic peripheral hyperinsulinemia via a one-week, reduced-carbohydrate...

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Bibliographic Details
Main Authors: Justin M. Gregory, T. Jordan Smith, Sara H. Duffus, David Brooks, M. Naweed Akbar, Margaret-Anne Huntley, JoAnn A. Gottlieb, Lauren M. LeStourgeon, Christopher S. Wilson, Joshua A. Beckman, Alan D. Cherrington
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cardiovascular Diabetology
Subjects:
Endothelial dysfunction
Endothelial function
Hyperinsulinemia
Insulin resistance
Insulin sensitivity
Reduced-carbohydrate diet
Online Access:https://doi.org/10.1186/s12933-025-02658-z
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