Dose-sparing effect of two adjuvant formulations with a pandemic influenza A/H7N9 vaccine: A randomized, double-blind, placebo-controlled, phase 1 clinical trial.

Dose-sparing effect of two adjuvant formulations with a pandemic influenza A/H7N9 vaccine: A randomized, double-blind, placebo-controlled, phase 1 clinical trial.

The emergence of potentially pandemic viruses has resulted in preparedness efforts to develop candidate vaccines and adjuvant formulations. We evaluated the dose-sparing effect and safety of two distinct squalene-based oil-in-water adjuvant emulsion formulations (IB160 and SE) with influenza A/H7N9...

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Main Authors: Tazio Vanni, Beatriz C Thomé, Erin Sparrow, Martin Friede, Christopher B Fox, Anna Marie Beckmann, Chuong Huynh, Gabriella Mondini, Daniela H Silveira, Juliana Y K Viscondi, Patrícia Emilia Braga, Anderson da Silva, Maria da Graça Salomão, Roberta O Piorelli, Joane P Santos, Vera Lúcia Gattás, Maria Beatriz B Lucchesi, Mayra M M de Oliveira, Marcelo E Koike, Esper G Kallas, Lucia M A Campos, Eduardo B Coelho, Marilda A M Siqueira, Cristiana C Garcia, Milene Dias Miranda, Terezinha M Paiva, Maria do Carmo S T Timenetsky, Eduardo A Adami, Milena A Akamatsu, Paulo Lee Ho, Alexander R Precioso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0274943&type=printable
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