A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention
Sulfadoxine-pyrimethamine (SP) is the standard of care for Plasmodium falciparum malaria chemoprevention among pregnant women, infants and children. Developing alternative chemoprevention products and other prevention products, such as vaccines and monoclonal antibodies, requires significant investm...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-02-01
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| Series: | Parasitology |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0031182025000071/type/journal_article |
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| author | Thiery Masserey Lydia Braunack-Mayer R Scott Miller Jörg J Möhrle Melissa A Penny |
| author_facet | Thiery Masserey Lydia Braunack-Mayer R Scott Miller Jörg J Möhrle Melissa A Penny |
| author_sort | Thiery Masserey |
| collection | DOAJ |
| description | Sulfadoxine-pyrimethamine (SP) is the standard of care for Plasmodium falciparum malaria chemoprevention among pregnant women, infants and children. Developing alternative chemoprevention products and other prevention products, such as vaccines and monoclonal antibodies, requires significant investment. However, knowledge gaps surrounding the activity of SP and resistance put these investments at risk. Therefore, we reviewed SP’s combined antimalarial action, including the individual antiplasmodial components, other antimicrobial effects, impact on malaria immunity development and continued effectiveness in settings with high SP resistance. We created a roadmap of non-clinical and clinical evidence to better understand the effectiveness of SP for chemoprevention and inform the development of new prevention tools. |
| format | Article |
| id | doaj-art-3733fa5960354c1a99f9b42f93d21abe |
| institution | DOAJ |
| issn | 0031-1820 1469-8161 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Parasitology |
| spelling | doaj-art-3733fa5960354c1a99f9b42f93d21abe2025-08-20T03:07:05ZengCambridge University PressParasitology0031-18201469-81612025-02-0115213314210.1017/S0031182025000071A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemopreventionThiery Masserey0https://orcid.org/0000-0003-2482-463XLydia Braunack-Mayer1https://orcid.org/0000-0001-5511-0053R Scott Miller2Jörg J Möhrle3Melissa A Penny4Swiss Tropical and Public Health Institute, Allschwil, Switzerland University of Basel, Basel, SwitzerlandSwiss Tropical and Public Health Institute, Allschwil, Switzerland University of Basel, Basel, SwitzerlandGates Medical Research Institute, Cambridge MA, USASwiss Tropical and Public Health Institute, Allschwil, Switzerland University of Basel, Basel, SwitzerlandSwiss Tropical and Public Health Institute, Allschwil, Switzerland University of Basel, Basel, Switzerland The Kids Research Institute Australia, Nedlands, WA, Australia Centre for Child Health Research, University of Western Australia, Crawley, WA, AustraliaSulfadoxine-pyrimethamine (SP) is the standard of care for Plasmodium falciparum malaria chemoprevention among pregnant women, infants and children. Developing alternative chemoprevention products and other prevention products, such as vaccines and monoclonal antibodies, requires significant investment. However, knowledge gaps surrounding the activity of SP and resistance put these investments at risk. Therefore, we reviewed SP’s combined antimalarial action, including the individual antiplasmodial components, other antimicrobial effects, impact on malaria immunity development and continued effectiveness in settings with high SP resistance. We created a roadmap of non-clinical and clinical evidence to better understand the effectiveness of SP for chemoprevention and inform the development of new prevention tools.https://www.cambridge.org/core/product/identifier/S0031182025000071/type/journal_articlemalariamechanisms of actionpreventionresistancesulfadoxine-pyrimethamine |
| spellingShingle | Thiery Masserey Lydia Braunack-Mayer R Scott Miller Jörg J Möhrle Melissa A Penny A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention Parasitology malaria mechanisms of action prevention resistance sulfadoxine-pyrimethamine |
| title | A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention |
| title_full | A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention |
| title_fullStr | A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention |
| title_full_unstemmed | A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention |
| title_short | A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention |
| title_sort | roadmap for understanding sulfadoxine pyrimethamine in malaria chemoprevention |
| topic | malaria mechanisms of action prevention resistance sulfadoxine-pyrimethamine |
| url | https://www.cambridge.org/core/product/identifier/S0031182025000071/type/journal_article |
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