Higher oxidative balance score is associated with lower female infertility: a cross-sectional study
BackgroundAn imbalance of the pro-oxidant and antioxidant profiles in the body contributes to the development of diseases, including female infertility.MethodsIn this study, we performed a secondary analysis of the National Health and Nutrition Examination Survey and calculated the values of oxidati...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1484756/full |
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| author | Xiong Lei Xiling Liu Chunchun Yu Lijing Xia Liwen Zhou Can Yao Zhixiao Xu |
| author_facet | Xiong Lei Xiling Liu Chunchun Yu Lijing Xia Liwen Zhou Can Yao Zhixiao Xu |
| author_sort | Xiong Lei |
| collection | DOAJ |
| description | BackgroundAn imbalance of the pro-oxidant and antioxidant profiles in the body contributes to the development of diseases, including female infertility.MethodsIn this study, we performed a secondary analysis of the National Health and Nutrition Examination Survey and calculated the values of oxidative balance score (OBS). A weighted logistic regression model was used to explore the potential relationship between OBS (continuous factor and quartile set) and female infertility, and the P for trend was calculated. Subgroup analyses were also carried out further to explore the association between OBS and female infertility, and the P for interactions were obtained.ResultsThere were 1,626 females (aged 18 to 45) included in the study, including 198 with infertility and a prevalence of approximately 13.28%. Multifactorial logistic regression showed a 5% decrease in infertility for each unit increased in OBS (OR, 0.95; 95% CI, 0.92 to 0.98). When OBS was used as a categorical variable, female infertility decreased by 60% in the highest OBS group compared with the lowest OBS group (OR, 0.40; 95% CI, 0.21 to 0.74). In addition, subgroup analyses showed that the negative association between OBS and infertility was significant in the non-chronic disease (hypertension and diabetes) population, those with less than a high school educational background, poverty-to-income ratio (1 to 3), and those with more than 30 years of age.ConclusionHigher OBS was negatively associated with female infertility. Further prospective studies are needed to determine causality and to provide new perspectives on female infertility in the context of diet and lifestyle. |
| format | Article |
| id | doaj-art-3732019e56b64fd38424173b237cfc19 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-3732019e56b64fd38424173b237cfc192025-08-20T02:18:43ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-12-011110.3389/fnut.2024.14847561484756Higher oxidative balance score is associated with lower female infertility: a cross-sectional studyXiong Lei0Xiling Liu1Chunchun Yu2Lijing Xia3Liwen Zhou4Can Yao5Zhixiao Xu6Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Gastroenterology, Minhang District Central Hospital of Shanghai, Fudan University, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaBackgroundAn imbalance of the pro-oxidant and antioxidant profiles in the body contributes to the development of diseases, including female infertility.MethodsIn this study, we performed a secondary analysis of the National Health and Nutrition Examination Survey and calculated the values of oxidative balance score (OBS). A weighted logistic regression model was used to explore the potential relationship between OBS (continuous factor and quartile set) and female infertility, and the P for trend was calculated. Subgroup analyses were also carried out further to explore the association between OBS and female infertility, and the P for interactions were obtained.ResultsThere were 1,626 females (aged 18 to 45) included in the study, including 198 with infertility and a prevalence of approximately 13.28%. Multifactorial logistic regression showed a 5% decrease in infertility for each unit increased in OBS (OR, 0.95; 95% CI, 0.92 to 0.98). When OBS was used as a categorical variable, female infertility decreased by 60% in the highest OBS group compared with the lowest OBS group (OR, 0.40; 95% CI, 0.21 to 0.74). In addition, subgroup analyses showed that the negative association between OBS and infertility was significant in the non-chronic disease (hypertension and diabetes) population, those with less than a high school educational background, poverty-to-income ratio (1 to 3), and those with more than 30 years of age.ConclusionHigher OBS was negatively associated with female infertility. Further prospective studies are needed to determine causality and to provide new perspectives on female infertility in the context of diet and lifestyle.https://www.frontiersin.org/articles/10.3389/fnut.2024.1484756/fullfemale infertilityoxidative balance scoreNHANESdietarylifestyle |
| spellingShingle | Xiong Lei Xiling Liu Chunchun Yu Lijing Xia Liwen Zhou Can Yao Zhixiao Xu Higher oxidative balance score is associated with lower female infertility: a cross-sectional study Frontiers in Nutrition female infertility oxidative balance score NHANES dietary lifestyle |
| title | Higher oxidative balance score is associated with lower female infertility: a cross-sectional study |
| title_full | Higher oxidative balance score is associated with lower female infertility: a cross-sectional study |
| title_fullStr | Higher oxidative balance score is associated with lower female infertility: a cross-sectional study |
| title_full_unstemmed | Higher oxidative balance score is associated with lower female infertility: a cross-sectional study |
| title_short | Higher oxidative balance score is associated with lower female infertility: a cross-sectional study |
| title_sort | higher oxidative balance score is associated with lower female infertility a cross sectional study |
| topic | female infertility oxidative balance score NHANES dietary lifestyle |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1484756/full |
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