Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer

Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer

Abstract The prognosis of advanced CRC is poor, and identifying key genes related to CRC is vital for improving CRC prognosis. Our research used univariate Cox analysis and Mendelian randomization (MR) analysis to identify key prognostic genes in CRC. Multiple datasets such as the nomogram model and...

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Bibliographic Details
Main Authors: Meng Hu, Haotian Dong, Chujia Chen, Chengyuan Ye, Jianing Yan, Xuan Yu, Guoliang Ye, Yongfu Shao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Colorectal cancer
Mendelian randomization
Single-cell RNA sequencing
Prognosis
Immune microenvironment
MMRN1
Online Access:https://doi.org/10.1038/s41598-025-10354-x
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