The Functions of PPARs in Aging and Longevity
Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and man...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2007/39654 |
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| _version_ | 1832552557558366208 |
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| author | Adnan Erol |
| author_facet | Adnan Erol |
| author_sort | Adnan Erol |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitive
transcription factors and their dyregulated activations seem to be major culprits for these
pathological processes. Drugs targeting PPARs activity are already in widespread clinical use;
however, based on these concepts, this review highlights the understanding of the role of
PPARs in aging and indicates the necessary particular attention for the potential therapeutic
uses of current PPAR agonists in age-associated diseases. |
| format | Article |
| id | doaj-art-373136222c4b4f57935fd3706257cad7 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-373136222c4b4f57935fd3706257cad72025-02-03T05:58:17ZengWileyPPAR Research1687-47571687-47652007-01-01200710.1155/2007/3965439654The Functions of PPARs in Aging and LongevityAdnan Erol0Department of Internal Medicine, Faculty of Medicine, Celal Bayar University, Manisa 45020, TurkeyPeroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitive transcription factors and their dyregulated activations seem to be major culprits for these pathological processes. Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases.http://dx.doi.org/10.1155/2007/39654 |
| spellingShingle | Adnan Erol The Functions of PPARs in Aging and Longevity PPAR Research |
| title | The Functions of PPARs in Aging and Longevity |
| title_full | The Functions of PPARs in Aging and Longevity |
| title_fullStr | The Functions of PPARs in Aging and Longevity |
| title_full_unstemmed | The Functions of PPARs in Aging and Longevity |
| title_short | The Functions of PPARs in Aging and Longevity |
| title_sort | functions of ppars in aging and longevity |
| url | http://dx.doi.org/10.1155/2007/39654 |
| work_keys_str_mv | AT adnanerol thefunctionsofpparsinagingandlongevity AT adnanerol functionsofpparsinagingandlongevity |