Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies
Background: Dengue is a global health concern, with half of the world’s population at risk and no antiviral treatment available. This Phase 0 study investigated dengue infections among household contacts (HHCs) of dengue index cases (ICs) and assessed the feasibility of conducting a Phase 2 trial fo...
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2025-06-01
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| author | Erik Koehne Liesbeth Van Wesenbeeck Martin L. Hibberd Annemie Buelens Michiko Toizumi Kim De Clerck Leen Vijgen Ole Lagatie Lucy Masdin Hien Anh Thi Nguyen Hoang Huy Le Duc Anh Dang Mai Kim Huynh Lien Thuy Le Trieu Bao Nguyên Stephane Hue Hung Thai Do Guillermo Herrera-Taracena Freya Rasschaert Lay-Myint Yoshida |
| author_facet | Erik Koehne Liesbeth Van Wesenbeeck Martin L. Hibberd Annemie Buelens Michiko Toizumi Kim De Clerck Leen Vijgen Ole Lagatie Lucy Masdin Hien Anh Thi Nguyen Hoang Huy Le Duc Anh Dang Mai Kim Huynh Lien Thuy Le Trieu Bao Nguyên Stephane Hue Hung Thai Do Guillermo Herrera-Taracena Freya Rasschaert Lay-Myint Yoshida |
| author_sort | Erik Koehne |
| collection | DOAJ |
| description | Background: Dengue is a global health concern, with half of the world’s population at risk and no antiviral treatment available. This Phase 0 study investigated dengue infections among household contacts (HHCs) of dengue index cases (ICs) and assessed the feasibility of conducting a Phase 2 trial for a novel antiviral. Methods: Participants were enrolled in Nha Trang, Vietnam, from April 2022 to February 2023. Dengue ICs were identified within 72 h of fever onset, and their healthy adult HHCs enrolled within 48 h. Blood samples and questionnaires were collected bi-weekly for four weeks, with a follow-up visit on day 40. DENV RT-qPCR, NS1, and anti-DENV IgM/IgG ELISAs were performed. Results: Overall, 130 dengue ICs and 301 HHCs were enrolled, with 91.7% (276/301) completing all follow-up visits. Baseline anti-DENV IgG showed prior dengue infections in 262/301 HHCs (87.0%). Fifty HHCs were excluded from the HHC infection analysis based on evidence of a DENV infection (viral load [VL], NS1, IgM, and IgG results) at enrollment. During follow-up, 2.0% of HHCs (5/251) had DENV infections based on virological parameters (DENV RNA and/or NS1 positivity), and anti-DENV IgG/IgM seroconversion was detected in 7.2% (18/251). Conclusions: This study demonstrated the operational feasibility of a dengue IC-HHC design for a Phase 2 trial. |
| format | Article |
| id | doaj-art-372abe3c85bd4ff0b60d707a25ed8ee6 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Viruses |
| spelling | doaj-art-372abe3c85bd4ff0b60d707a25ed8ee62025-08-20T03:26:52ZengMDPI AGViruses1999-49152025-06-0117685910.3390/v17060859Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention StudiesErik Koehne0Liesbeth Van Wesenbeeck1Martin L. Hibberd2Annemie Buelens3Michiko Toizumi4Kim De Clerck5Leen Vijgen6Ole Lagatie7Lucy Masdin8Hien Anh Thi Nguyen9Hoang Huy Le10Duc Anh Dang11Mai Kim Huynh12Lien Thuy Le13Trieu Bao Nguyên14Stephane Hue15Hung Thai Do16Guillermo Herrera-Taracena17Freya Rasschaert18Lay-Myint Yoshida19Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanJohnson & Johnson, 2340 Beerse, BelgiumFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UKJohnson & Johnson, 2340 Beerse, BelgiumDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanJohnson & Johnson, 2340 Beerse, BelgiumJohnson & Johnson, 2340 Beerse, BelgiumJohnson & Johnson, 2340 Beerse, BelgiumFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UKNational Institute of Hygiene and Epidemiology, Hanoi 100000, VietnamNational Institute of Hygiene and Epidemiology, Hanoi 100000, VietnamNational Institute of Hygiene and Epidemiology, Hanoi 100000, VietnamPasteur Institute in Nha Trang, Nha Trang 650000, VietnamPasteur Institute in Nha Trang, Nha Trang 650000, VietnamPasteur Institute in Nha Trang, Nha Trang 650000, VietnamFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UKPasteur Institute in Nha Trang, Nha Trang 650000, VietnamJohnson & Johnson, Horsham, PA 19044, USAJohnson & Johnson, 2340 Beerse, BelgiumDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanBackground: Dengue is a global health concern, with half of the world’s population at risk and no antiviral treatment available. This Phase 0 study investigated dengue infections among household contacts (HHCs) of dengue index cases (ICs) and assessed the feasibility of conducting a Phase 2 trial for a novel antiviral. Methods: Participants were enrolled in Nha Trang, Vietnam, from April 2022 to February 2023. Dengue ICs were identified within 72 h of fever onset, and their healthy adult HHCs enrolled within 48 h. Blood samples and questionnaires were collected bi-weekly for four weeks, with a follow-up visit on day 40. DENV RT-qPCR, NS1, and anti-DENV IgM/IgG ELISAs were performed. Results: Overall, 130 dengue ICs and 301 HHCs were enrolled, with 91.7% (276/301) completing all follow-up visits. Baseline anti-DENV IgG showed prior dengue infections in 262/301 HHCs (87.0%). Fifty HHCs were excluded from the HHC infection analysis based on evidence of a DENV infection (viral load [VL], NS1, IgM, and IgG results) at enrollment. During follow-up, 2.0% of HHCs (5/251) had DENV infections based on virological parameters (DENV RNA and/or NS1 positivity), and anti-DENV IgG/IgM seroconversion was detected in 7.2% (18/251). Conclusions: This study demonstrated the operational feasibility of a dengue IC-HHC design for a Phase 2 trial.https://www.mdpi.com/1999-4915/17/6/859dengueinfectionhousehold contactscommunityVietnam |
| spellingShingle | Erik Koehne Liesbeth Van Wesenbeeck Martin L. Hibberd Annemie Buelens Michiko Toizumi Kim De Clerck Leen Vijgen Ole Lagatie Lucy Masdin Hien Anh Thi Nguyen Hoang Huy Le Duc Anh Dang Mai Kim Huynh Lien Thuy Le Trieu Bao Nguyên Stephane Hue Hung Thai Do Guillermo Herrera-Taracena Freya Rasschaert Lay-Myint Yoshida Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies Viruses dengue infection household contacts community Vietnam |
| title | Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies |
| title_full | Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies |
| title_fullStr | Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies |
| title_full_unstemmed | Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies |
| title_short | Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies |
| title_sort | dengue infections among household contacts of symptomatic index cases implications for community based intervention studies |
| topic | dengue infection household contacts community Vietnam |
| url | https://www.mdpi.com/1999-4915/17/6/859 |
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