Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species
Phlomis species (family Lamiaceae) are highly valued as food and herbal medicine. The present study is designed to investigate the chemical composition and antioxidant and enzyme inhibitory activities of extracts from P. fruticosa, P. herba‐venti, and P. kurdica aerial parts. Different classes of me...
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| Format: | Article |
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Wiley-VCH
2025-08-01
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| Series: | ChemistryOpen |
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| Online Access: | https://doi.org/10.1002/open.202500004 |
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| author | Sakina Yagi Gokhan Zengin Mehmet Veysi Cetiz Zoltán Cziáky József Jeko Muammer Bahşi Uğur Çakılcıoğlu Halbay Turumtay Abdurrahman Aktumsek |
| author_facet | Sakina Yagi Gokhan Zengin Mehmet Veysi Cetiz Zoltán Cziáky József Jeko Muammer Bahşi Uğur Çakılcıoğlu Halbay Turumtay Abdurrahman Aktumsek |
| author_sort | Sakina Yagi |
| collection | DOAJ |
| description | Phlomis species (family Lamiaceae) are highly valued as food and herbal medicine. The present study is designed to investigate the chemical composition and antioxidant and enzyme inhibitory activities of extracts from P. fruticosa, P. herba‐venti, and P. kurdica aerial parts. Different classes of metabolites, including phenolic acids, phenylethanoids, flavonoids, iridoids, organic acids, terpenes, and fatty acids, are identified in the three species, with methanol as the best solvent to recover bioactive compounds from the three species in addition to ethyl acetate for P. kurdica. Around 70% methanol extract of P. herba‐venti exerts the best radical scavenging and ions‐reducing properties, while its methanol extract exhibits the highest acetylcholinesterase inhibitory activity. The ethyl acetate extract of P. fruticosa displays the best chelating power, and its other polar extracts have the highest total antioxidant activity. Furthermore, molecular docking and molecular dynamics simulations have underscored the therapeutic potential of bioactive compounds, including isoverbascoside, samioside, forsythoside B, and hattushoside. In conclusion, the study indicates that these three Phlomis species are a rich source of bioactive molecules with possible therapeutic applications, and the selection of appropriate extraction solvents is crucial for the targeted biological activity. |
| format | Article |
| id | doaj-art-372548b42d6e4dbda53b4ae34505efda |
| institution | Kabale University |
| issn | 2191-1363 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryOpen |
| spelling | doaj-art-372548b42d6e4dbda53b4ae34505efda2025-08-21T12:05:32ZengWiley-VCHChemistryOpen2191-13632025-08-01148n/an/a10.1002/open.202500004Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis SpeciesSakina Yagi0Gokhan Zengin1Mehmet Veysi Cetiz2Zoltán Cziáky3József Jeko4Muammer Bahşi5Uğur Çakılcıoğlu6Halbay Turumtay7Abdurrahman Aktumsek8Department of Botany Faculty of Science University of Khartoum Khartoum 11115 SudanDepartment of Biology Science Faculty Selcuk University 42130 Konya TürkiyeDepartment of Medical Biochemistry Faculty of Medicine Harran University 63290 Sanliurfa TurkeyAgricultural and Molecular Research and Service Institute University of Nyíregyháza 001 Nyíregyháza HU‐4400 HungaryAgricultural and Molecular Research and Service Institute University of Nyíregyháza 001 Nyíregyháza HU‐4400 HungaryFaculty of Education Department of Primary Education Fırat University Elazığ TurkeyPertek Sakine Genç Vocational School Munzur University 62500 Pertek,Tunceli TurkeyDepartment of Energy System Engineering Karadeniz Technical University 61830 Trabzon TurkeyDepartment of Biology Science Faculty Selcuk University 42130 Konya TürkiyePhlomis species (family Lamiaceae) are highly valued as food and herbal medicine. The present study is designed to investigate the chemical composition and antioxidant and enzyme inhibitory activities of extracts from P. fruticosa, P. herba‐venti, and P. kurdica aerial parts. Different classes of metabolites, including phenolic acids, phenylethanoids, flavonoids, iridoids, organic acids, terpenes, and fatty acids, are identified in the three species, with methanol as the best solvent to recover bioactive compounds from the three species in addition to ethyl acetate for P. kurdica. Around 70% methanol extract of P. herba‐venti exerts the best radical scavenging and ions‐reducing properties, while its methanol extract exhibits the highest acetylcholinesterase inhibitory activity. The ethyl acetate extract of P. fruticosa displays the best chelating power, and its other polar extracts have the highest total antioxidant activity. Furthermore, molecular docking and molecular dynamics simulations have underscored the therapeutic potential of bioactive compounds, including isoverbascoside, samioside, forsythoside B, and hattushoside. In conclusion, the study indicates that these three Phlomis species are a rich source of bioactive molecules with possible therapeutic applications, and the selection of appropriate extraction solvents is crucial for the targeted biological activity.https://doi.org/10.1002/open.202500004antioxidantsenzyme inhibitionP. herba‐ventiP. kurdicaPhlomis fruticosaphytoconstituents |
| spellingShingle | Sakina Yagi Gokhan Zengin Mehmet Veysi Cetiz Zoltán Cziáky József Jeko Muammer Bahşi Uğur Çakılcıoğlu Halbay Turumtay Abdurrahman Aktumsek Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species ChemistryOpen antioxidants enzyme inhibition P. herba‐venti P. kurdica Phlomis fruticosa phytoconstituents |
| title | Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species |
| title_full | Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species |
| title_fullStr | Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species |
| title_full_unstemmed | Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species |
| title_short | Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species |
| title_sort | chemical characterization antioxidant and enzyme inhibitory activities of different extracts from three phlomis species |
| topic | antioxidants enzyme inhibition P. herba‐venti P. kurdica Phlomis fruticosa phytoconstituents |
| url | https://doi.org/10.1002/open.202500004 |
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