Advances in Canine Anesthesia: Physiologically Based Pharmacokinetic Modeling for Predicting Propofol Plasma Profiles in Canines with Hepatic Impairment

Advances in Canine Anesthesia: Physiologically Based Pharmacokinetic Modeling for Predicting Propofol Plasma Profiles in Canines with Hepatic Impairment

<b>Background</b>: A PBPK model allows the prediction of the concentration of drug amounts in different tissues and organs over time and can be used to simulate and optimize different therapeutic protocols in healthy and sick individuals. The objective of this work was to create a PBPK m...

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Bibliographic Details
Main Authors: Lucas Wamser Fonseca Gonzaga, Beatriz Monte Egito, João Bosco Costa Coelho, Gabriela Pereira Souza, Frederico Severino Martins, Marcos Ferrante
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
precision anesthesia
PK model
dose individualization
Online Access:https://www.mdpi.com/1424-8247/17/12/1720
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