Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review

Intra-abdominal candidiasis (IAC), with or without candidemia, is a common condition in patients in intensive care units (ICUs). Early diagnosis of IAC remains a challenge for clinicians despite new biomarkers. Early and appropriate antifungal treatment, which is associated with better clinical outc...

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Main Authors: Marco Marotta Pais, Rafael Zaragoza, Ignacio Martín-Loeches, Frederic F. Gómez-Bertomeu, Alejandro Rodríguez
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Journal of Fungi
Subjects:
Online Access:https://www.mdpi.com/2309-608X/11/5/362
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author Marco Marotta Pais
Rafael Zaragoza
Ignacio Martín-Loeches
Frederic F. Gómez-Bertomeu
Alejandro Rodríguez
author_facet Marco Marotta Pais
Rafael Zaragoza
Ignacio Martín-Loeches
Frederic F. Gómez-Bertomeu
Alejandro Rodríguez
author_sort Marco Marotta Pais
collection DOAJ
description Intra-abdominal candidiasis (IAC), with or without candidemia, is a common condition in patients in intensive care units (ICUs). Early diagnosis of IAC remains a challenge for clinicians despite new biomarkers. Early and appropriate antifungal treatment, which is associated with better clinical outcomes, is negatively affected by the increased isolation of non-albicans <i>Candida</i> strains that are resistant to the commonly used azoles and echinocandins. Based on the pharmacokinetic (PK) and pharmacodynamic (PD) properties of the different treatment options, liposomal amphotericin B, rezafungin or high doses of anidulafungin appear to be the most appropriate first-line options for complicated IAC in ICUs.
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series Journal of Fungi
spelling doaj-art-371c3ffd7a4e4834a512db0a013962372025-08-20T01:56:16ZengMDPI AGJournal of Fungi2309-608X2025-05-0111536210.3390/jof11050362Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative ReviewMarco Marotta Pais0Rafael Zaragoza1Ignacio Martín-Loeches2Frederic F. Gómez-Bertomeu3Alejandro Rodríguez4Critical Care Department, Hospital Universitari de Tarragona Joan XXIII, Mallafré Guasch 4, 43007 Tarragona, SpainCritical Care Department, Hospital Universitario Dr. Peset, Av. Gaspar Aguilar 90, 46017 Valencia, SpainDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James’ Hospital, D08 NHY1 Dublin, IrelandDepartment of Medicine and Surgery, Faculty of Medicine and Health Sciences, Rovira & Virgili University, 43005 Tarragona, SpainCritical Care Department, Hospital Universitari de Tarragona Joan XXIII, Mallafré Guasch 4, 43007 Tarragona, SpainIntra-abdominal candidiasis (IAC), with or without candidemia, is a common condition in patients in intensive care units (ICUs). Early diagnosis of IAC remains a challenge for clinicians despite new biomarkers. Early and appropriate antifungal treatment, which is associated with better clinical outcomes, is negatively affected by the increased isolation of non-albicans <i>Candida</i> strains that are resistant to the commonly used azoles and echinocandins. Based on the pharmacokinetic (PK) and pharmacodynamic (PD) properties of the different treatment options, liposomal amphotericin B, rezafungin or high doses of anidulafungin appear to be the most appropriate first-line options for complicated IAC in ICUs.https://www.mdpi.com/2309-608X/11/5/362invasive candidiasisantifungal treatmentdiagnosisoutcome
spellingShingle Marco Marotta Pais
Rafael Zaragoza
Ignacio Martín-Loeches
Frederic F. Gómez-Bertomeu
Alejandro Rodríguez
Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review
Journal of Fungi
invasive candidiasis
antifungal treatment
diagnosis
outcome
title Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review
title_full Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review
title_fullStr Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review
title_full_unstemmed Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review
title_short Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review
title_sort management of intra abdominal candidiasis in intensive care setting a narrative review
topic invasive candidiasis
antifungal treatment
diagnosis
outcome
url https://www.mdpi.com/2309-608X/11/5/362
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