High cut-off hemodialysis vs. high flux hemodialysis for free light chain removal: a case report and literature review
Objective To compare the high cut-off hemodialysis with high flux hemodialysis for free light chain removal,and to review literatures concerned. Methods A male aged59 was admitted due to " fatigue more than one year,aggravated two days". He felt fatigue one year ago and was diagnosed as mu...
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Editorial Department of Journal of Clinical Nephrology
2018-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | XU Feng-bo SUN Yi XUE Fei |
| author_facet | XU Feng-bo SUN Yi XUE Fei |
| author_sort | XU Feng-bo |
| collection | DOAJ |
| description | Objective To compare the high cut-off hemodialysis with high flux hemodialysis for free light chain removal,and to review literatures concerned. Methods A male aged59 was admitted due to " fatigue more than one year,aggravated two days". He felt fatigue one year ago and was diagnosed as multiple myeloma by bone marrow biopsy and increased free light chain. Then partial remission was achieved by thalidomide,adriamcin and dexamethasone. One week before,he felt weakness and chest pain,then a decrease in hemoglobin and acute renal failure were found,which was considered the recurrence of multiple myeloma. Cyclophosphamide,doxorubicin and dexamethasone chemotherapy was started. When the creatinine up to 611μmol/L,the hemodialysis treatment began. He received two times high flux hemodialysis( Fresenius FX60) first,then three times high cut-off hemodialysis( HCO2100). Time was four h and ultrafiltration was set at 0. 5 kg. Human albumin 10 g was replenished at high flux hemodialysis for 3. 5 h. The levels of serum FLCλ were detected by particle enhanced turbidimetric immunoassay,and those of serum albumin by automatic biochemical immunoassay before and after treatment.Results After two times high flux hemodialysis,serum levels of FLCλ were decreasedfrom 45. 9 to 36. 4 mg/L,and those of albumin changed from 31. 9 to 32. 7 mg/L respectively.After three times high cut-off hemodialysis,serum levels of FLC λ decreased from 42. 3 to 32. 1 mg/L,and those of albumin were decreased from 33 to 28 mg/L( 10 g albumin was added in each high cut-off hemodialysis). Conclusions We didn’t find the superiority of high cut-off hemodialysis over high flux hemodialysis for serum FLC removal in multiple myeloma on renal replacement therapy.During four hours of high cut-off hemodialysis,albumin loss can be effectively prevented by intravenous administration of 10 g albumin. |
| format | Article |
| id | doaj-art-3715ced44c824f449b66af0df1e58f45 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2018-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-3715ced44c824f449b66af0df1e58f452025-08-20T01:51:10ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902018-01-01303357915994High cut-off hemodialysis vs. high flux hemodialysis for free light chain removal: a case report and literature reviewXU Feng-boSUN YiXUE FeiObjective To compare the high cut-off hemodialysis with high flux hemodialysis for free light chain removal,and to review literatures concerned. Methods A male aged59 was admitted due to " fatigue more than one year,aggravated two days". He felt fatigue one year ago and was diagnosed as multiple myeloma by bone marrow biopsy and increased free light chain. Then partial remission was achieved by thalidomide,adriamcin and dexamethasone. One week before,he felt weakness and chest pain,then a decrease in hemoglobin and acute renal failure were found,which was considered the recurrence of multiple myeloma. Cyclophosphamide,doxorubicin and dexamethasone chemotherapy was started. When the creatinine up to 611μmol/L,the hemodialysis treatment began. He received two times high flux hemodialysis( Fresenius FX60) first,then three times high cut-off hemodialysis( HCO2100). Time was four h and ultrafiltration was set at 0. 5 kg. Human albumin 10 g was replenished at high flux hemodialysis for 3. 5 h. The levels of serum FLCλ were detected by particle enhanced turbidimetric immunoassay,and those of serum albumin by automatic biochemical immunoassay before and after treatment.Results After two times high flux hemodialysis,serum levels of FLCλ were decreasedfrom 45. 9 to 36. 4 mg/L,and those of albumin changed from 31. 9 to 32. 7 mg/L respectively.After three times high cut-off hemodialysis,serum levels of FLC λ decreased from 42. 3 to 32. 1 mg/L,and those of albumin were decreased from 33 to 28 mg/L( 10 g albumin was added in each high cut-off hemodialysis). Conclusions We didn’t find the superiority of high cut-off hemodialysis over high flux hemodialysis for serum FLC removal in multiple myeloma on renal replacement therapy.During four hours of high cut-off hemodialysis,albumin loss can be effectively prevented by intravenous administration of 10 g albumin.http://www.lcszb.com/thesisDetails?columnId=57915994&Fpath=home&index=0Free light chainHigh cut-off hemodialysisHigh flux hemodialysis |
| spellingShingle | XU Feng-bo SUN Yi XUE Fei High cut-off hemodialysis vs. high flux hemodialysis for free light chain removal: a case report and literature review Linchuang shenzangbing zazhi Free light chain High cut-off hemodialysis High flux hemodialysis |
| title | High cut-off hemodialysis vs. high flux hemodialysis for free light chain removal: a case report and literature review |
| title_full | High cut-off hemodialysis vs. high flux hemodialysis for free light chain removal: a case report and literature review |
| title_fullStr | High cut-off hemodialysis vs. high flux hemodialysis for free light chain removal: a case report and literature review |
| title_full_unstemmed | High cut-off hemodialysis vs. high flux hemodialysis for free light chain removal: a case report and literature review |
| title_short | High cut-off hemodialysis vs. high flux hemodialysis for free light chain removal: a case report and literature review |
| title_sort | high cut off hemodialysis vs high flux hemodialysis for free light chain removal a case report and literature review |
| topic | Free light chain High cut-off hemodialysis High flux hemodialysis |
| url | http://www.lcszb.com/thesisDetails?columnId=57915994&Fpath=home&index=0 |
| work_keys_str_mv | AT xufengbo highcutoffhemodialysisvshighfluxhemodialysisforfreelightchainremovalacasereportandliteraturereview AT sunyi highcutoffhemodialysisvshighfluxhemodialysisforfreelightchainremovalacasereportandliteraturereview AT xuefei highcutoffhemodialysisvshighfluxhemodialysisforfreelightchainremovalacasereportandliteraturereview |