Modelling Potential Candidates for Targeted Auger Therapy
Targeted Auger emitters are being considered as a cancer treatment owing to the high linear energy transfer of Auger electrons. When targeted to cancers, this allows for a highly efficient treatment with a low risk of damage to surrounding healthy tissue. The purpose of this study was to determine t...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Biophysica |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4125/4/4/46 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850240288321175552 |
|---|---|
| author | Conor M. J. Buchanan Eric O. Aboagye Lee J. Evitts Michael J. D. Rushton Tim A. D. Smith |
| author_facet | Conor M. J. Buchanan Eric O. Aboagye Lee J. Evitts Michael J. D. Rushton Tim A. D. Smith |
| author_sort | Conor M. J. Buchanan |
| collection | DOAJ |
| description | Targeted Auger emitters are being considered as a cancer treatment owing to the high linear energy transfer of Auger electrons. When targeted to cancers, this allows for a highly efficient treatment with a low risk of damage to surrounding healthy tissue. The purpose of this study was to determine the most DNA-damaging Auger emitters from a range of radionuclides, some of which are clinically utilised. A Monte Carlo method-based software (Geant4-DNA version 10.7) was used to determine the energy deposition and number of DNA double-strand breaks from Auger (and internal conversion) electrons imposed on a tetranucleosome. The Auger emitters, <sup>119</sup>Sb and <sup>103</sup>Pd, have similar or slightly greater damaging properties compared to <sup>123</sup>I, <sup>111</sup>In, and <sup>89</sup>Zr. <sup>193m</sup>Pt demonstrated the greatest therapeutic potency. Whilst <sup>125</sup>I was highly damaging, its relatively long half-life (60 days) makes it less desirable for clinical use. Geant4-DNA modelling identified the radionuclide <sup>193m</sup>Pt as being highly favourable for use in radiotherapy. |
| format | Article |
| id | doaj-art-37043c23340646d4bc2b57ad08bfcd4e |
| institution | OA Journals |
| issn | 2673-4125 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biophysica |
| spelling | doaj-art-37043c23340646d4bc2b57ad08bfcd4e2025-08-20T02:00:54ZengMDPI AGBiophysica2673-41252024-12-014471172310.3390/biophysica4040046Modelling Potential Candidates for Targeted Auger TherapyConor M. J. Buchanan0Eric O. Aboagye1Lee J. Evitts2Michael J. D. Rushton3Tim A. D. Smith4Nuclear Futures Institute, Bangor University, Gwynedd LL57 2DG, UKDepartment of Surgery and Cancer, Faculty of Medicine, Commonwealth Building, Hammersmith Campus, Imperial College London, London W12 0NN, UKNuclear Futures Institute, Bangor University, Gwynedd LL57 2DG, UKNuclear Futures Institute, Bangor University, Gwynedd LL57 2DG, UKNuclear Futures Institute, Bangor University, Gwynedd LL57 2DG, UKTargeted Auger emitters are being considered as a cancer treatment owing to the high linear energy transfer of Auger electrons. When targeted to cancers, this allows for a highly efficient treatment with a low risk of damage to surrounding healthy tissue. The purpose of this study was to determine the most DNA-damaging Auger emitters from a range of radionuclides, some of which are clinically utilised. A Monte Carlo method-based software (Geant4-DNA version 10.7) was used to determine the energy deposition and number of DNA double-strand breaks from Auger (and internal conversion) electrons imposed on a tetranucleosome. The Auger emitters, <sup>119</sup>Sb and <sup>103</sup>Pd, have similar or slightly greater damaging properties compared to <sup>123</sup>I, <sup>111</sup>In, and <sup>89</sup>Zr. <sup>193m</sup>Pt demonstrated the greatest therapeutic potency. Whilst <sup>125</sup>I was highly damaging, its relatively long half-life (60 days) makes it less desirable for clinical use. Geant4-DNA modelling identified the radionuclide <sup>193m</sup>Pt as being highly favourable for use in radiotherapy.https://www.mdpi.com/2673-4125/4/4/46radionuclidetargetedaugercancer |
| spellingShingle | Conor M. J. Buchanan Eric O. Aboagye Lee J. Evitts Michael J. D. Rushton Tim A. D. Smith Modelling Potential Candidates for Targeted Auger Therapy Biophysica radionuclide targeted auger cancer |
| title | Modelling Potential Candidates for Targeted Auger Therapy |
| title_full | Modelling Potential Candidates for Targeted Auger Therapy |
| title_fullStr | Modelling Potential Candidates for Targeted Auger Therapy |
| title_full_unstemmed | Modelling Potential Candidates for Targeted Auger Therapy |
| title_short | Modelling Potential Candidates for Targeted Auger Therapy |
| title_sort | modelling potential candidates for targeted auger therapy |
| topic | radionuclide targeted auger cancer |
| url | https://www.mdpi.com/2673-4125/4/4/46 |
| work_keys_str_mv | AT conormjbuchanan modellingpotentialcandidatesfortargetedaugertherapy AT ericoaboagye modellingpotentialcandidatesfortargetedaugertherapy AT leejevitts modellingpotentialcandidatesfortargetedaugertherapy AT michaeljdrushton modellingpotentialcandidatesfortargetedaugertherapy AT timadsmith modellingpotentialcandidatesfortargetedaugertherapy |