Modelling Potential Candidates for Targeted Auger Therapy
Targeted Auger emitters are being considered as a cancer treatment owing to the high linear energy transfer of Auger electrons. When targeted to cancers, this allows for a highly efficient treatment with a low risk of damage to surrounding healthy tissue. The purpose of this study was to determine t...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Biophysica |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4125/4/4/46 |
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| Summary: | Targeted Auger emitters are being considered as a cancer treatment owing to the high linear energy transfer of Auger electrons. When targeted to cancers, this allows for a highly efficient treatment with a low risk of damage to surrounding healthy tissue. The purpose of this study was to determine the most DNA-damaging Auger emitters from a range of radionuclides, some of which are clinically utilised. A Monte Carlo method-based software (Geant4-DNA version 10.7) was used to determine the energy deposition and number of DNA double-strand breaks from Auger (and internal conversion) electrons imposed on a tetranucleosome. The Auger emitters, <sup>119</sup>Sb and <sup>103</sup>Pd, have similar or slightly greater damaging properties compared to <sup>123</sup>I, <sup>111</sup>In, and <sup>89</sup>Zr. <sup>193m</sup>Pt demonstrated the greatest therapeutic potency. Whilst <sup>125</sup>I was highly damaging, its relatively long half-life (60 days) makes it less desirable for clinical use. Geant4-DNA modelling identified the radionuclide <sup>193m</sup>Pt as being highly favourable for use in radiotherapy. |
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| ISSN: | 2673-4125 |