New Insights into the Role of the Immune Microenvironment in Breast Carcinoma
Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocy...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/785317 |
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| author | Luis de la Cruz-Merino Antonio Barco-Sánchez Fernando Henao Carrasco Esteban Nogales Fernández Ana Vallejo Benítez Javier Brugal Molina Antonio Martínez Peinado Ana Grueso López Manuel Ruiz Borrego Manuel Codes Manuel de Villena Víctor Sánchez-Margalet Adoración Nieto-García Emilio Alba Conejo Noelia Casares Lagar José Ibáñez Martínez |
| author_facet | Luis de la Cruz-Merino Antonio Barco-Sánchez Fernando Henao Carrasco Esteban Nogales Fernández Ana Vallejo Benítez Javier Brugal Molina Antonio Martínez Peinado Ana Grueso López Manuel Ruiz Borrego Manuel Codes Manuel de Villena Víctor Sánchez-Margalet Adoración Nieto-García Emilio Alba Conejo Noelia Casares Lagar José Ibáñez Martínez |
| author_sort | Luis de la Cruz-Merino |
| collection | DOAJ |
| description | Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) and myeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer. In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore. In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice and could be useful to design successful therapeutic strategies in the future. |
| format | Article |
| id | doaj-art-36ffc2f0d4ef48a583d787aa755ca221 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-36ffc2f0d4ef48a583d787aa755ca2212025-08-20T03:55:01ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/785317785317New Insights into the Role of the Immune Microenvironment in Breast CarcinomaLuis de la Cruz-Merino0Antonio Barco-Sánchez1Fernando Henao Carrasco2Esteban Nogales Fernández3Ana Vallejo Benítez4Javier Brugal Molina5Antonio Martínez Peinado6Ana Grueso López7Manuel Ruiz Borrego8Manuel Codes Manuel de Villena9Víctor Sánchez-Margalet10Adoración Nieto-García11Emilio Alba Conejo12Noelia Casares Lagar13José Ibáñez Martínez14Clinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainBiochemistry Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainPathology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainPathology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainBiochemistry Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainBiochemistry Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainStatistics Department, Universidad de Sevilla, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainClinical Oncology Department, Hospital Universitario Virgen de la Victoria, Campus de Teatinos s/n, 29010 Málaga, SpainCentro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pío XII 55, 31008 Pamplona, SpainPathology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, SpainRecently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) and myeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer. In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore. In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice and could be useful to design successful therapeutic strategies in the future.http://dx.doi.org/10.1155/2013/785317 |
| spellingShingle | Luis de la Cruz-Merino Antonio Barco-Sánchez Fernando Henao Carrasco Esteban Nogales Fernández Ana Vallejo Benítez Javier Brugal Molina Antonio Martínez Peinado Ana Grueso López Manuel Ruiz Borrego Manuel Codes Manuel de Villena Víctor Sánchez-Margalet Adoración Nieto-García Emilio Alba Conejo Noelia Casares Lagar José Ibáñez Martínez New Insights into the Role of the Immune Microenvironment in Breast Carcinoma Clinical and Developmental Immunology |
| title | New Insights into the Role of the Immune Microenvironment in Breast Carcinoma |
| title_full | New Insights into the Role of the Immune Microenvironment in Breast Carcinoma |
| title_fullStr | New Insights into the Role of the Immune Microenvironment in Breast Carcinoma |
| title_full_unstemmed | New Insights into the Role of the Immune Microenvironment in Breast Carcinoma |
| title_short | New Insights into the Role of the Immune Microenvironment in Breast Carcinoma |
| title_sort | new insights into the role of the immune microenvironment in breast carcinoma |
| url | http://dx.doi.org/10.1155/2013/785317 |
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