Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management
Salivary gland neoplasms (SGNs) are rare and heterogeneous tumors in the head and neck region. Although progress has been recently made in revealing the molecular landscape of salivary glands tumors, it is limited and appears to be the tip of the iceberg. Some genetic aberrations include chromosomal...
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Galenos Publishing House
2022-06-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-63139 |
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| author | Anam YOUSAF Sarina SULONG Baharudin ABDULLAH Norhafiza Mat LAZIM |
| author_facet | Anam YOUSAF Sarina SULONG Baharudin ABDULLAH Norhafiza Mat LAZIM |
| author_sort | Anam YOUSAF |
| collection | DOAJ |
| description | Salivary gland neoplasms (SGNs) are rare and heterogeneous tumors in the head and neck region. Although progress has been recently made in revealing the molecular landscape of salivary glands tumors, it is limited and appears to be the tip of the iceberg. Some genetic aberrations include chromosomal translocations, such as CRTC1/3-MAML2 in mucoepidermoid carcinoma, g MYB-NFIB gene fusions in adenoid cystic carcinoma, and PLAG1-HMGA2 gene changes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma. These chromosomal translocations provide fresh insights into the molecular etiology of diverse SGNs and aid in their classification and in approaching treatment. In future, these genetic variations may serve as critical tools for diagnosing salivary gland tumors and optimizing the management as well as prognosis of patients. This review presents the most recent advances in the molecular pathology of salivary gland cancers, with an emphasis on distinguishing molecular features that can be used for optimizing current patient management. |
| format | Article |
| id | doaj-art-36fda08084f942e9bc42c7b4b863cc76 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-36fda08084f942e9bc42c7b4b863cc762025-01-30T07:13:14ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062022-06-0137219420210.4274/MMJ.galenos.2022.63139MEDJ-63139Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current ManagementAnam YOUSAF0Sarina SULONG1Baharudin ABDULLAH2Norhafiza Mat LAZIM3Department of Molecular Pathology, Pakistan Kidney and Liver Institute & Research Center, Lahore, PakistanHuman Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, MalaysiaDepartment of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, MalaysiaDepartment of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, MalaysiaSalivary gland neoplasms (SGNs) are rare and heterogeneous tumors in the head and neck region. Although progress has been recently made in revealing the molecular landscape of salivary glands tumors, it is limited and appears to be the tip of the iceberg. Some genetic aberrations include chromosomal translocations, such as CRTC1/3-MAML2 in mucoepidermoid carcinoma, g MYB-NFIB gene fusions in adenoid cystic carcinoma, and PLAG1-HMGA2 gene changes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma. These chromosomal translocations provide fresh insights into the molecular etiology of diverse SGNs and aid in their classification and in approaching treatment. In future, these genetic variations may serve as critical tools for diagnosing salivary gland tumors and optimizing the management as well as prognosis of patients. This review presents the most recent advances in the molecular pathology of salivary gland cancers, with an emphasis on distinguishing molecular features that can be used for optimizing current patient management.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-63139salivary glands tumorchromosomal aberrationsbenign tumormalignant tumorgenetic mutationshypermethylation |
| spellingShingle | Anam YOUSAF Sarina SULONG Baharudin ABDULLAH Norhafiza Mat LAZIM Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management Medeniyet Medical Journal salivary glands tumor chromosomal aberrations benign tumor malignant tumor genetic mutations hypermethylation |
| title | Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management |
| title_full | Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management |
| title_fullStr | Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management |
| title_full_unstemmed | Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management |
| title_short | Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management |
| title_sort | heterogeneity of genetic landscapes in salivary gland tumors and their critical roles in current management |
| topic | salivary glands tumor chromosomal aberrations benign tumor malignant tumor genetic mutations hypermethylation |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-63139 |
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