Radiation Field Characterization for Cellular Irradiation: Application for Low Energy Beams
The interaction of radiation with biological tissues may cause some damage. To quantify it, studying cells in vitro is one methodology for analyzing dose deposition in biological tissues because once exposed to radiation, different methods can quantify the biological damage. However, biological tis...
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| Format: | Article |
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2023-04-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://www.sbpr.org.br/revista/index.php/REVISTA/article/view/2210 |
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| author | Rafael Guimarães Malanga Thatiane Alves Pianoschi Cassiana Viccari Henrique Trombini Franciele Faccio Busatto Dinara Jaqueline Moura Mirko Salomon Alva-Sánchez |
| author_facet | Rafael Guimarães Malanga Thatiane Alves Pianoschi Cassiana Viccari Henrique Trombini Franciele Faccio Busatto Dinara Jaqueline Moura Mirko Salomon Alva-Sánchez |
| author_sort | Rafael Guimarães Malanga |
| collection | DOAJ |
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The interaction of radiation with biological tissues may cause some damage. To quantify it, studying cells in vitro is one methodology for analyzing dose deposition in biological tissues because once exposed to radiation, different methods can quantify the biological damage. However, biological tissue culture exposure forms mostly employ high-energy beams (MeV). Thus, this study aims to characterize the radiation field from X-ray equipment using thermoluminescent dosimeters (TLD), to establish an in vitro irradiation protocol of breast cancer and glioblastoma cells for low energies. First, the central axis alignment test was performed to ensure the equipment followed the Normativa IN 90. Then the variation of radiation intensity was analyzed for a 5 x 5 cm² field at distances between 30 and 90 cm from the focal point to the detector. Subsequently, TLD immersed in breast cancer and glioblastoma cellular media were irradiated in a 106 kV and 71 mAs beam to evaluate the dose in cellular media. Simulations were performed with the PENELOPE code to compare with experimental results. The result of the central axis alignment showed that the equipment complies with the current Normativa. The dose distributions for the evaluated distances were more homogeneous for the 40 cm distance, with a standard deviation of 1.7% and 0.9% of the distributions obtained with the TLD and simulation, respectively. Thus, the irradiation field for low energy beams was characterized for a 5 x 5 cm² field for 106 kV and 71 mAs beams at a DFS of 40 cm.
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| format | Article |
| id | doaj-art-36fa7f6cc30b4b2c9ddf2afa732fecee |
| institution | OA Journals |
| issn | 2319-0612 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-36fa7f6cc30b4b2c9ddf2afa732fecee2025-08-20T02:37:35ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122023-04-01111ARadiation Field Characterization for Cellular Irradiation: Application for Low Energy BeamsRafael Guimarães Malanga0Thatiane Alves Pianoschi1Cassiana Viccari2Henrique Trombini3Franciele Faccio Busatto4Dinara Jaqueline Moura5Mirko Salomon Alva-Sánchez6Universidade Federal de Ciências de Porto Alegre (UFCSPA)Federal University of Health Sciences of Porto Alegre University of Sao PauloFederal University of Health Sciences of Porto Alegre Federal University of Health Sciences of Porto Alegre Federal University of Health Sciences of Porto Alegre Federal University of Health Sciences of Porto Alegre The interaction of radiation with biological tissues may cause some damage. To quantify it, studying cells in vitro is one methodology for analyzing dose deposition in biological tissues because once exposed to radiation, different methods can quantify the biological damage. However, biological tissue culture exposure forms mostly employ high-energy beams (MeV). Thus, this study aims to characterize the radiation field from X-ray equipment using thermoluminescent dosimeters (TLD), to establish an in vitro irradiation protocol of breast cancer and glioblastoma cells for low energies. First, the central axis alignment test was performed to ensure the equipment followed the Normativa IN 90. Then the variation of radiation intensity was analyzed for a 5 x 5 cm² field at distances between 30 and 90 cm from the focal point to the detector. Subsequently, TLD immersed in breast cancer and glioblastoma cellular media were irradiated in a 106 kV and 71 mAs beam to evaluate the dose in cellular media. Simulations were performed with the PENELOPE code to compare with experimental results. The result of the central axis alignment showed that the equipment complies with the current Normativa. The dose distributions for the evaluated distances were more homogeneous for the 40 cm distance, with a standard deviation of 1.7% and 0.9% of the distributions obtained with the TLD and simulation, respectively. Thus, the irradiation field for low energy beams was characterized for a 5 x 5 cm² field for 106 kV and 71 mAs beams at a DFS of 40 cm. https://www.sbpr.org.br/revista/index.php/REVISTA/article/view/2210irradiation fieldlow energy beamsin vitro cells |
| spellingShingle | Rafael Guimarães Malanga Thatiane Alves Pianoschi Cassiana Viccari Henrique Trombini Franciele Faccio Busatto Dinara Jaqueline Moura Mirko Salomon Alva-Sánchez Radiation Field Characterization for Cellular Irradiation: Application for Low Energy Beams Brazilian Journal of Radiation Sciences irradiation field low energy beams in vitro cells |
| title | Radiation Field Characterization for Cellular Irradiation: Application for Low Energy Beams |
| title_full | Radiation Field Characterization for Cellular Irradiation: Application for Low Energy Beams |
| title_fullStr | Radiation Field Characterization for Cellular Irradiation: Application for Low Energy Beams |
| title_full_unstemmed | Radiation Field Characterization for Cellular Irradiation: Application for Low Energy Beams |
| title_short | Radiation Field Characterization for Cellular Irradiation: Application for Low Energy Beams |
| title_sort | radiation field characterization for cellular irradiation application for low energy beams |
| topic | irradiation field low energy beams in vitro cells |
| url | https://www.sbpr.org.br/revista/index.php/REVISTA/article/view/2210 |
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