InDel mutations within the bovine PER2 gene are significantly associated with reproductive traits
Functioning as a key regulator of circadian rhythms, the PER2 gene exerts a substantial impact on the reproductive traits of animals. However, the effect of the PER2 gene on ovarian development remains unclear. In order to examine the relationship between bovine reproductive trait and the PER2 gene,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Animal Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10495398.2024.2397806 |
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| author | Yuanzhe Yang Jiajun Song Siyuan Shen Yongsheng Wang Chuanying Pan Jiyao Wu Xianyong Lan |
| author_facet | Yuanzhe Yang Jiajun Song Siyuan Shen Yongsheng Wang Chuanying Pan Jiyao Wu Xianyong Lan |
| author_sort | Yuanzhe Yang |
| collection | DOAJ |
| description | Functioning as a key regulator of circadian rhythms, the PER2 gene exerts a substantial impact on the reproductive traits of animals. However, the effect of the PER2 gene on ovarian development remains unclear. In order to examine the relationship between bovine reproductive trait and the PER2 gene, a total of 901 ovarian samples were collected, categorized into different oestrus cycles (proestrus, oestrus, post-oestrus, anoestrous), and subjected to analysis for two potential insertion/deletions (InDels) in the PER2 gene. Through agarose gel electrophoresis and DNA sequencing, two polymorphic deletion mutations (P2-D5-bp, P3-D13-bp) were identified. Furthermore, a significant association between mature follicle diameter and P2-D5-bp was found (P < 0.05). Additionally, several significant correlations with ovarian length, width, height, and white body diameter were found for P3-D13-bp (P < 0.05). These findings suggested that the bovine PER2 gene plays an important role in above-mentioned reproductive traits, offering new avenues for improving cow fertility through marker-assisted selection (MAS). |
| format | Article |
| id | doaj-art-36f79236eaa549eabdbe05ab4d983e8a |
| institution | DOAJ |
| issn | 1049-5398 1532-2378 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Biotechnology |
| spelling | doaj-art-36f79236eaa549eabdbe05ab4d983e8a2025-08-20T03:13:50ZengTaylor & Francis GroupAnimal Biotechnology1049-53981532-23782024-12-0135110.1080/10495398.2024.2397806InDel mutations within the bovine PER2 gene are significantly associated with reproductive traitsYuanzhe Yang0Jiajun Song1Siyuan Shen2Yongsheng Wang3Chuanying Pan4Jiyao Wu5Xianyong Lan6College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, ChinaCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, ChinaCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, ChinaFunctioning as a key regulator of circadian rhythms, the PER2 gene exerts a substantial impact on the reproductive traits of animals. However, the effect of the PER2 gene on ovarian development remains unclear. In order to examine the relationship between bovine reproductive trait and the PER2 gene, a total of 901 ovarian samples were collected, categorized into different oestrus cycles (proestrus, oestrus, post-oestrus, anoestrous), and subjected to analysis for two potential insertion/deletions (InDels) in the PER2 gene. Through agarose gel electrophoresis and DNA sequencing, two polymorphic deletion mutations (P2-D5-bp, P3-D13-bp) were identified. Furthermore, a significant association between mature follicle diameter and P2-D5-bp was found (P < 0.05). Additionally, several significant correlations with ovarian length, width, height, and white body diameter were found for P3-D13-bp (P < 0.05). These findings suggested that the bovine PER2 gene plays an important role in above-mentioned reproductive traits, offering new avenues for improving cow fertility through marker-assisted selection (MAS).https://www.tandfonline.com/doi/10.1080/10495398.2024.2397806BovinePER2insertion/deletion (InDel)ovarian traitscorpus albicans |
| spellingShingle | Yuanzhe Yang Jiajun Song Siyuan Shen Yongsheng Wang Chuanying Pan Jiyao Wu Xianyong Lan InDel mutations within the bovine PER2 gene are significantly associated with reproductive traits Animal Biotechnology Bovine PER2 insertion/deletion (InDel) ovarian traits corpus albicans |
| title | InDel mutations within the bovine PER2 gene are significantly associated with reproductive traits |
| title_full | InDel mutations within the bovine PER2 gene are significantly associated with reproductive traits |
| title_fullStr | InDel mutations within the bovine PER2 gene are significantly associated with reproductive traits |
| title_full_unstemmed | InDel mutations within the bovine PER2 gene are significantly associated with reproductive traits |
| title_short | InDel mutations within the bovine PER2 gene are significantly associated with reproductive traits |
| title_sort | indel mutations within the bovine per2 gene are significantly associated with reproductive traits |
| topic | Bovine PER2 insertion/deletion (InDel) ovarian traits corpus albicans |
| url | https://www.tandfonline.com/doi/10.1080/10495398.2024.2397806 |
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