THE IMPORTANCE OF GLOMERULAR C3 ACCUMULATION IN ELDERLY PATIENTS WITH PRIMARY MEMBRANOUS NEPHROPATHY

THE IMPORTANCE OF GLOMERULAR C3 ACCUMULATION IN ELDERLY PATIENTS WITH PRIMARY MEMBRANOUS NEPHROPATHY

Objective: The purpose of this study was to investigate the impact of glomerular C3 accumulation density on clinical, histopathological parameters and outcomes in elderly (>60 years) individuals with primary membranous nephropathy (PMN). Material and Methods: In this study, we examined the pa...

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Main Authors: Özgür Akın Oto, Şafak Mirioğlu, Ahmet Burak Dirim, Seda Şafak, Nurana Güller, Erol Demir, Ayşe Serra Artan, Mesude Yasemin Özlük, Ali Rıza Uçar, Lala Soltanova, Kanan Nuriyev, Halil Yazıcı, Yaşar Kerem Çalışkan
Format: Article
Language:English
Published: Istanbul University Press 2022-10-01
Series:İstanbul Tıp Fakültesi Dergisi
Subjects:
complementary system
c3
older age
membranous nephropathy
Online Access:https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/3027A5A777624FBF9488F0CB7EF1AA7A
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Summary:Objective: The purpose of this study was to investigate the impact of glomerular C3 accumulation density on clinical, histopathological parameters and outcomes in elderly (>60 years) individuals with primary membranous nephropathy (PMN). Material and Methods: In this study, we examined the patients (n=105) in two groups according to the C3 staining density in kidney biopsy samples as low intensity (C3: 1+; LI group) and high intensity (C3: 2+ or C3: 3+; HI group). The primary endpoint of our study was the end-stage renal disease, and the secondary endpoints were the development of partial remission (PR) or complete remission (CR). Results: At the end of the follow-up (mean 30.6 months), more patients achieved the primary endpoint, and fewer patients achieved the secondary endpoints in the HI group compared to the LI group. (p=0.015 and p=0.016, respectively). Moreover, the glomerular filtration rate (eGFR) was lower (p<0.001), and proteinuria was higher in the HI group (p=0.018). Kaplan-Meier survival analysis revealed that renal survival (p=0.031) was lower in the HI group compared to the LI group. In the multivariate logistic regression analyses, no predictive parameters could be detected for the endpoints.Conclusion: Intense glomerular C3 deposition in elderly (>60 years) patients with PMN may be related to poor clinical outcomes.
ISSN:1305-6441

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