Research progress on the formation and regulation of viable but nonculturable cells in biofilms
The formation and regulation of viable but nonculturable (VBNC) cells in biofilms is a cutting-edge topic in microbiology research. Although there has been controversy over the concept of the VBNC state in the past, its significant impact on ecological balance and public safety cannot be denied. The...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhejiang University Press
2024-08-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
| Subjects: | |
| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2023.10.181 |
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| Summary: | The formation and regulation of viable but nonculturable (VBNC) cells in biofilms is a cutting-edge topic in microbiology research. Although there has been controversy over the concept of the VBNC state in the past, its significant impact on ecological balance and public safety cannot be denied. The formation of VBNC cells regulated by multiple factors has gradually been revealed, including pathways such as gene expression and protein synthesis. These studies lay the foundation for analyzing the survival strategies and ecological adaptability of VBNC cells. This review summarized VBNC cells from multiple perspectives, including the discussion of their definition, the presence of VBNC cells in biofilms, their formation triggers and relevant mechanisms, and the regulation and prevention of VBNC cells. The focus of future research will be to explore the function and significance of VBNC cells, intervene in their formation, solve related problems in innovative ways, and reveal the molecular mechanisms and metabolic pathways of VBNC cells in detail. |
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| ISSN: | 1008-9209 2097-5155 |