EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation
We studied 36 glioblastoma cases at HC-UNICAMP from 2008 to 2012 and classified the immunohistochemical distribution of the wild-type epidermal growth factor receptor (EGFR), mutated forms of p53 protein and isocitrate dehydrogenase-1 (IDH-1) and murine double protein 2 (MDM2). Immunostaining findin...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2015-07-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700561&lng=en&tlng=en |
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| author | Richard Murdoch Montgomery Luciano de Souza Queiroz Fabio Rogerio |
| author_facet | Richard Murdoch Montgomery Luciano de Souza Queiroz Fabio Rogerio |
| author_sort | Richard Murdoch Montgomery |
| collection | DOAJ |
| description | We studied 36 glioblastoma cases at HC-UNICAMP from 2008 to 2012 and classified the immunohistochemical distribution of the wild-type epidermal growth factor receptor (EGFR), mutated forms of p53 protein and isocitrate dehydrogenase-1 (IDH-1) and murine double protein 2 (MDM2). Immunostaining findings were correlated with clinical data and response to treatment (surgery, chemotherapy and radiotherapy). About 97% of the tumors were primary, most of them localized in the frontal lobe. Mean time free of clinical or symptomatic disease and free time of radiological disease were 7.56 and 7.14 months, respectively. We observed a significant positive correlation between expressions of p53 and MDM2, EGFR and MDM2. Clinical, radiological and overall survivals also showed a significant positive correlation. p53 staining and clinical survival showed a significant negative correlation. The current series provides clinical and histopathological data that contribute to knowledge on glioblastoma in Brazilians. |
| format | Article |
| id | doaj-art-36e3b960a82949dea25aee83fe3bccb8 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-36e3b960a82949dea25aee83fe3bccb82025-08-20T02:01:41ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272015-07-0173756156810.1590/0004-282X20150059S0004-282X2015000700561EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlationRichard Murdoch MontgomeryLuciano de Souza QueirozFabio RogerioWe studied 36 glioblastoma cases at HC-UNICAMP from 2008 to 2012 and classified the immunohistochemical distribution of the wild-type epidermal growth factor receptor (EGFR), mutated forms of p53 protein and isocitrate dehydrogenase-1 (IDH-1) and murine double protein 2 (MDM2). Immunostaining findings were correlated with clinical data and response to treatment (surgery, chemotherapy and radiotherapy). About 97% of the tumors were primary, most of them localized in the frontal lobe. Mean time free of clinical or symptomatic disease and free time of radiological disease were 7.56 and 7.14 months, respectively. We observed a significant positive correlation between expressions of p53 and MDM2, EGFR and MDM2. Clinical, radiological and overall survivals also showed a significant positive correlation. p53 staining and clinical survival showed a significant negative correlation. The current series provides clinical and histopathological data that contribute to knowledge on glioblastoma in Brazilians.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700561&lng=en&tlng=englioblastomaneurocirurgiatemozolomidaimunoistoquímicaprognóstico clínico |
| spellingShingle | Richard Murdoch Montgomery Luciano de Souza Queiroz Fabio Rogerio EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation Arquivos de Neuro-Psiquiatria glioblastoma neurocirurgia temozolomida imunoistoquímica prognóstico clínico |
| title | EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation |
| title_full | EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation |
| title_fullStr | EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation |
| title_full_unstemmed | EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation |
| title_short | EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation |
| title_sort | egfr p53 idh 1 and mdm2 immunohistochemical analysis in glioblastoma therapeutic and prognostic correlation |
| topic | glioblastoma neurocirurgia temozolomida imunoistoquímica prognóstico clínico |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700561&lng=en&tlng=en |
| work_keys_str_mv | AT richardmurdochmontgomery egfrp53idh1andmdm2immunohistochemicalanalysisinglioblastomatherapeuticandprognosticcorrelation AT lucianodesouzaqueiroz egfrp53idh1andmdm2immunohistochemicalanalysisinglioblastomatherapeuticandprognosticcorrelation AT fabiorogerio egfrp53idh1andmdm2immunohistochemicalanalysisinglioblastomatherapeuticandprognosticcorrelation |