Design and characterization of G-quadruplex RNA aptamers reveal RNA-binding by KDM5 lysine demethylases

Design and characterization of G-quadruplex RNA aptamers reveal RNA-binding by KDM5 lysine demethylases

Here, we show that the histone lysine demethylases KDM5A and KDM5B can bind to RNA through interaction with G-quadruplexes, despite neither being categorized as RNA- nor G-quadruplex binding proteins across numerous experimental large-scale and computational studies. In addition to characterizing th...

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Bibliographic Details
Main Authors: Johanna Luige, Thomas Conrad, Alexandros Armaos, Annita Louloupi, Anna Vincent, David Meierhofer, Michael Gajhede, Gian Gaetano Tartaglia, Ulf Andersson Vang Ørom
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
RNA
RNA binding proteins
G-quadruplex
Protein complexes
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037025002429
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